典型文献
Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes
文献摘要：
The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical micro-biome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenor-rhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth.
文献关键词：
中图分类号：
作者姓名：
Zhuye Jie;Chen Chen;Lilan Hao;Fei Li;Liju Song;Xiaowei Zhang;Jie Zhu;Liu Tian;Xin Tong;Kaiye Cai;Zhe Zhang;Yanmei Ju;Xinlei Yu;Ying Li;Hongcheng Zhou;Haorong Lu;Xuemei Qiu;Qiang Li;Yunli Liao;Dongsheng Zhou;Heng Lian;Yong Zuo;Xiaomin Chen;Weiqiao Rao;Yan Ren;Yuan Wang;Jin Zi;Rong Wang;Na Liu;Jinghua Wu;Wei Zhang;Xiao Liu;Yang Zong;Weibin Liu;Liang Xiao;Yong Hou;Xun Xu;Huanming Yang;Jian Wang;Karsten Kristiansen;Huijue Jia
作者机构：
BGI-Shenzhen,Shenzhen 518083,China;Shenzhen Key Laboratory of Human Comrnensal Microorganisms and Health Research,BGI-Shenzhen,Shenzhen 518083,China;Department of Biology,University of Copenhagen,Copenhagen DK-2100,Denmark;Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome,BGI-Shenzhen,Shenzhen 518083,China;BG1 Education Center,University of Chinese Academy of Sciences,Shenzhen 518083,China;China National Genebank,BGI-Shenzhen,Shenzhen 518120,China;BGI-Qingdao,BGI-Shenzhen,Qingdao 266555,China;James D.Watson Institute of Genome Sciences,Hangzhou 310058,China
文献出处：
引用格式：
[1]Zhuye Jie;Chen Chen;Lilan Hao;Fei Li;Liju Song;Xiaowei Zhang;Jie Zhu;Liu Tian;Xin Tong;Kaiye Cai;Zhe Zhang;Yanmei Ju;Xinlei Yu;Ying Li;Hongcheng Zhou;Haorong Lu;Xuemei Qiu;Qiang Li;Yunli Liao;Dongsheng Zhou;Heng Lian;Yong Zuo;Xiaomin Chen;Weiqiao Rao;Yan Ren;Yuan Wang;Jin Zi;Rong Wang;Na Liu;Jinghua Wu;Wei Zhang;Xiao Liu;Yang Zong;Weibin Liu;Liang Xiao;Yong Hou;Xun Xu;Huanming Yang;Jian Wang;Karsten Kristiansen;Huijue Jia-.Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes)[J].基因组蛋白质组与生物信息学报（英文版）,2022(02):304-321
A类：
Vagino,omes,lactobacilli,vagino,dysmenor,Lactobacilli
B类：
Life,History,Recorded,cervical,Microbiome,Along,Multi,vagina,contains,least,billion,microbial,cells,dominated,by,Here,perform,metagenomic,shotgun,sequencing,fecal,samples,from,cohort,Chinese,women,reproductive,well,salivary,second,Factors,such,pregnancy,history,delivery,cesarean,section,breastfeeding,were,more,important,than,menstrual,cycle,shaping,information,would,necessary,before,trying,interpret,differences,between,data,Greater,proportion,Bifidobacterium,breve,was,seen,older,sexual,debut,relative,abundance,especially,Lactobacillus,crispatus,negatively,associated,Potential,markers,lack,regularity,heavy,flow,rhea,contraceptives,also,identified,rare,during,post,menopause,Other,features,mood,fluctuations,facial,speckles,could,potentially,predicted,Gut,microbiomes,plasma,vitamins,metals,amino,acids,hormones,showed,associations,Our,results,offer,unprecedented,glimpse,into,microbiota,female,tract,call,international,collaborations,better,understand,its,term,health,impact,other,settings,infection,birth
AB值：
0.633312
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