典型文献
Molecular insights into onset of autoimmunity in SARS-CoV-2 infected patients
文献摘要：
Some of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients are facing long-term devastating effects like induction of autoimmune diseases. Here, I discuss molecular mechanisms and risk factors involved in the induction of autoimmune diseases after SARS-CoV-2 infections. Transcript editing genes were upregulated during SARS-CoV-2 infections, which might have edited host gene transcripts and paved the way for autoantigens generation and presented as nonself to generate autoantibodies followed by auto immunogenicity after SARS-CoV-2 infections. Therefore, some SARS-CoV-2 patients acquire autoimmunity. The transient and/or innocuous autoimmune response in some SARS-CoV-2 infected patients may be due to a lack of repeated production of autoantibodies to host autoantigens and/or viral antigens, which are needed to boost autoimmune response. In the future, SARS-CoV-2 mediated autoimmune disease onset will be a challenging task. Therefore, possible preventive measures and strategies to minimize and/or preclude such SARS-CoV-2 mediated autoimmune diseases have been presented in this commentary.
文献关键词：
autoimmunity;cytokine storm;mutations;RNA editing;SARS-CoV-2 pathogenesis;type I interferons
中图分类号：
作者姓名：
Laxminarayana Dama
作者机构：
Sathya Krishna Genomics LLC, Winston-Salem, North Carolina, USA
文献出处：
引用格式：
[1]Laxminarayana Dama-.Molecular insights into onset of autoimmunity in SARS-CoV-2 infected patients)[J].风湿病与自身免疫（英文）,2022(04):198-202
A类：
autoantigens,nonself,innocuous
B类：
Molecular,insights,into,onset,autoimmunity,SARS,CoV,infected,patients,Some,severe,acute,respiratory,syndrome,coronavirus,are,facing,long,term,devastating,effects,like,induction,autoimmune,diseases,Here,discuss,molecular,mechanisms,risk,factors,involved,after,infections,Transcript,editing,were,upregulated,during,which,might,have,edited,host,transcripts,paved,way,generation,presented,generate,autoantibodies,followed,by,immunogenicity,Therefore,some,acquire,transient,response,may,due,lack,repeated,production,viral,needed,boost,In,future,mediated,will,challenging,task,possible,preventive,measures,strategies,minimize,preclude,such,been,this,commentary,cytokine,storm,mutations,pathogenesis,type,interferons
AB值：
0.542708
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