典型文献
The effects of inactivated SARS-CoV -2 vaccination andsubsequent infection of pregnant mice on the behaviors of offspring
文献摘要：
The mass inoculation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines to induce herd immunity is one of the most effective measures we can deploy in the fight against coronavirus disease 2019 (COVID-19). Pregnant women are prone to a higher risk of COVID-19, and maternal infection is a risk fac-tor for a range of neurological disorders leading to abnormal behavior in adulthood. However, there are limited clinical data to support whether vaccination or infection post-immunization in pregnant women can affect the behavioral cognition of fetuses in adulthood. In this study, human angiotensin-converting enzyme 2 pregnant mice (F0 generation) were immunized with CoronaVac and then infected with SARS-CoV-2. Subsequently, we analyzed the behavioral cognition of their adult offspring (F1 gen-eration) using the open-field test and Morris water maze test. The adult F1 generation did not exhibit any impairments in spontaneous locomotor activity or spatial refer-ence memory.
文献关键词：
中图分类号：
作者姓名：
Kaili Lin;Meixuan Liu;Lu Sun;Hongwei Qiao;Shunyi Wang;Sidan Pan;Hanjun Fu;Jingzhu Wang;Qiang Wei;Hong Gao
作者机构：
Institute of Laboratory Animal Science,Chinese Academy of Medical Sciencesand Comparative Medicine Center,Peking Union Medical College,Beijing,China
文献出处：
引用格式：
[1]Kaili Lin;Meixuan Liu;Lu Sun;Hongwei Qiao;Shunyi Wang;Sidan Pan;Hanjun Fu;Jingzhu Wang;Qiang Wei;Hong Gao-.The effects of inactivated SARS-CoV -2 vaccination andsubsequent infection of pregnant mice on the behaviors of offspring)[J].动物模型与实验医学（英文）,2022(05):430-435
A类：
andsubsequent
B类：
effects,inactivated,SARS,CoV,vaccination,infection,pregnant,mice,behaviors,offspring,mass,inoculation,severe,acute,respiratory,syndrome,coronavirus,vaccines,induce,herd,immunity,most,effective,measures,can,deploy,fight,against,disease,Pregnant,women,are,prone,higher,risk,maternal,fac,range,neurological,disorders,leading,abnormal,adulthood,However,there,limited,clinical,data,support,whether,post,immunization,affect,behavioral,cognition,fetuses,In,this,study,human,angiotensin,converting,enzyme,F0,generation,were,immunized,CoronaVac,then,infected,Subsequently,analyzed,their,using,open,field,test,Morris,water,maze,did,not,exhibit,any,impairments,spontaneous,locomotor,activity,spatial,refer,ence,memory
AB值：
0.640022
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
