典型文献
Acanthus leucostachyus leaf extracts promote excision wound healing in mice
文献摘要：
Objective: To evaluate the in vivo wound healing activity of Acanthus leucostachyus leaf extracts using an excision wound model in mice. Methods: Mice were divided into two groups of six animals in each group: the control group and the Acanthus leucostachyus extract-treated group. Healing potential was evaluated by determination of physical parameters (contraction rate, epithelialization period, and tensile strength), biochemical parameters (protein, DNA, and hydroxyproline content), the expression of growth factor and pro-inflammatory cytokines, as well as histological and ultrastructural observations. Results: Treatment with Acanthus leucostachyus leaf extracts markedly increased the rate of wound contraction, tensile strength, the concentrations of protein, DNA, and hydroxyproline, and the expression of growth factor, as well as promoted epithelialization, compared to the control. In addition, Acanthus leucostachyus leaf extracts significantly reduced the expression of pro-inflammatory cytokines. Histological and ultrastructural studies revealed the presence of thicker epithelial layer and smoother surface topography in the extract-treated group compared to the control. Conclusions: Acanthus leucostachyus leaf extracts show potent wound-healing activity and can be used as a wound healing agent.
文献关键词：
中图分类号：
作者姓名：
Deepjyoti Dev;Ashish Sarkar;Bishnupada Roy
作者机构：
Parasitology and Toxicology Laboratory,Department of Zoology,North-Eastern Hill University,Shillong-793022,Meghalaya,India
文献出处：
引用格式：
[1]Deepjyoti Dev;Ashish Sarkar;Bishnupada Roy-.Acanthus leucostachyus leaf extracts promote excision wound healing in mice)[J].亚太热带生物医学杂志（英文版）,2022(11):475-482
A类：
leucostachyus,epithelialization
B类：
Acanthus,leaf,extracts,excision,wound,healing,mice,Objective,To,vivo,activity,using,model,Methods,Mice,were,divided,into,two,groups,six,animals,each,control,treated,Healing,potential,was,evaluated,by,determination,physical,parameters,contraction,rate,period,tensile,strength,biochemical,protein,hydroxyproline,content,expression,growth,inflammatory,cytokines,well,histological,ultrastructural,observations,Results,Treatment,markedly,increased,concentrations,promoted,compared,In,addition,significantly,reduced,Histological,studies,revealed,presence,thicker,layer,smoother,surface,topography,Conclusions,show,be,used,agent
AB值：
0.433553
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