典型文献
Detailed approach toward the anti-hyperglycemic potential of Sterculia diversifolia G.Don against alloxan-induced in vivo hyperglycemia model
文献摘要：
OBJECTIVE:To investigate Sterculia diversifolia G.Don for potential anti-diabetic activity in the in vivo mouse model of alloxan-induced hyperglycemia.METHODS:Sterculia diversifolia(S.diversifolia)was subjected to extraction and isolation techniques and structural characterization of the isolated compounds were performed using spectroscopic methods.The acute toxicity test was performed by orally administering S.diversifolia in doses of 500-2000 mg/kg.For the assessment of anti-hyperglycemic activity,S.diversifolia bark and leaves extracts were administered orally in doses of 50,100,and 200 mg/kg,along with metformin(150 mg/kg,i.p)as positive control,after confirmation of alloxan(150 mg/kg,i.p.)induced hyperglycemia in BALB/c mice.Serum biochemical parameters were monitored for the period of study.RESULTS:The phytochemical studies showed the presence of quercetin and kaempferol in S.diversifolia.The IC50 values in the in vivo acute toxicity study revealed the safety margin of S.diversifolia bark(1166.66 mg/kg)and leaves(683.34 mg/kg)extracts.A significant attenuation of alloxan induced hyperglycemia was produced by S.diversifolia extracts at 50 mg/kg(P＜0.05),100 mg/kg(P＜0.05,＜0.01),and 150 mg/kg(P＜0.05,＜0.01,＜0.001)during 1-4 h,which was comparable to metformin(P＜0.001).Significant(P＜0.001)improvement appeared in blood hemoglobin,protein,cholesterol,triglycerides,urea,creatinine,HDL,and LDL of the stem bark and leaves extracts treated diabetic mice.CONCLUSION:These findings connote the usefulness of S.diversifolia as an anti-diabetic in traditional medicine and this might be attributed to the presence of quercetin and kaempferol,among other phytochemicals.
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作者姓名：
Fazle Rabbi;Amir Zada;Amna Nisar;Achyut Adhikari;Irfan Ullah;Shafiq Ur Rahman
作者机构：
Department of Pharmacy,Abasyn University Peshawar,Peshawar 25000,Khyber Pakhtunkhwa,Pakistan;Department of Pharmacy,University of Peshawar,Peshawar 25120,Khyber Pakhtunkhwa,Pakistan;Central Department of Chemistry,Tribhuvan University,Kritipur 44613,Kathmandu,Nepal;Department of Pharmacy,Sarhad University of Science and Information Technology,Peshawar,25000,Khyber Pakhtunkhwa,Pakistan;Department of Pharmacy,Shaheed Benazir Bhutto University,Sheringal,Dir(Upper),18000,Khyber Pakhtunkhwa,Pakistan
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引用格式：
[1]Fazle Rabbi;Amir Zada;Amna Nisar;Achyut Adhikari;Irfan Ullah;Shafiq Ur Rahman-.Detailed approach toward the anti-hyperglycemic potential of Sterculia diversifolia G.Don against alloxan-induced in vivo hyperglycemia model)[J].中医杂志（英文版）,2022(01):17-22
A类：
diversifolia,alloxan,connote
B类：
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AB值：
0.48986
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