Objective: To explore the anti-inflammatory and antioxidant effects of caraway on atopic dermatitis (AD) in mice. Methods: AD was induced in two stages, including sensitization and challenge with the application of 2,4 dinitrochlorobenzene 2％ and 0.2％, respectively. Clinical symptoms and histological analysis of the skin were assessed. The effects of caraway on oxidant/antioxidant parameters as well as Th1- and Th2-related cytokines were also evaluated. Results: Caraway reduced the severity of dermatitis in AD-induced mice, as evidenced by significant inhibition of Th2-related cytokines (IL-4 and IL-13) and increased Th1-related cytokine (IFN-γ). Additionally, treatment with caraway significantly increased superoxide dismutase and catalase activity and decreased the malondialdehyde level in the serum of AD mice. Furthermore, caraway inhibited the differentiation of Th2 cells while favoring Th1 cell differentiation in the spleen via regulating their master transcription factors GATA3 and T-bet. Conclusions: Caraway could improve AD autoimmune responses and could be considered a potential candidate to treat AD disease.

Fardin Khajepour;Mohammad Reza Zangouyee;Arezu Khosravimashizi;Ali Afgar;Vahideh Abdollahi;Shahriar Dabiri;Reza Nosratabadi

Department of Medical Immunology,Afzalipour Faculty of Medicine,Kerman University of Medical Sciences,Kerman,Iran;Research Center for Hydatid Disease in Iran,Afzalipour Faculty of Medicine,Kerman University of Medical Sciences,Kerman,Iran;Student Research Committee,Afzalipour Faculty of Medicine,Kerman University of Medical Sciences,Kerman,Iran;Department of Animal Biology,Kharazmi University,Tehran,Iran;Department of Pathology,Afzalipour Faculty of Medicine,Kerman University of Medical Sciences,Kerman,Iran;Pathology and Stem Cells Research Center,Afzalipour Faculty of Medicine,Kerman University of Medical Sciences,Kerman,Iran;Gastroenterology and Hepathology Research Center,Institute of Basic and Clinical Physiology Sciences,Kerman University of Medical Sciences,Kerman,Iran

亚太热带生物医学杂志（英文版）

[1]Fardin Khajepour;Mohammad Reza Zangouyee;Arezu Khosravimashizi;Ali Afgar;Vahideh Abdollahi;Shahriar Dabiri;Reza Nosratabadi-.Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice)[J].亚太热带生物医学杂志（英文版）,2022(10):421-429

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