典型文献
Antihepatofibrotic effect of Guizhifuling pill(桂枝茯苓丸)on carbon tetrachloride-induced liver fibrosis in mice
文献摘要：
OBJECTIVE:To evaluate the protective effects and the underlying mechanism of Guizhifuling pill(桂枝茯苓丸,GZFL)on carbon tetrachloride(CCl4)-induced hepatic fibrosis in mice.METHODS:Male ICR mice by intraperitoneally administered with 20％CCl4(mixed 1:4 in soybean oil)to induce liver fibrosis.Mice that underwent CCl4 were orally with GZFL.Using hematoxylin and eosin and Masson staining to examine the pathological changes in liver tissue.Serum biochemical parameters,antioxidant enzyme activity and proinflammatory cytokines was assessed.Nuclear factor-kappaB(NF-κB)pathway and nuclear factor-erythroid 2-related factor 2(Nrf2)family members were evaluated by Western blotting.RESULTS:Our findings indicated that GZFL could effectively suppress the progression of liver fibrosis in mice,which was determined based on the improvement in liver function and reduction of collagen deposition.GZFL treatment also decreased the level of cytokines and increased the activity of antioxidant enzymes in liver tissue.Moreover,GZFL exerted anti-inflammatory and antioxidant effects through regulating the Nrf2-mediated antioxidant system and inhibiting the NF-κB pathway.CONCLUSIONS:GZFL may prevent the progression of liver fibrosis by regulating the Nrf2/heme oxygenase-1 and NF-κB signaling pathways,thereby highlighting its role in the management of liver fibrosis.
文献关键词：
中图分类号：
作者姓名：
XU Baogui;ZHENG Jiawen;TIAN Xiaoxiao;YUAN Falei;LIU Zhongliang;YANG Zuisu;DING Xianjun
作者机构：
School of Food and Pharmacy,Zhejiang Ocean University;Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products,Zhoushan 316022,China;Department of Oncology,Zhoushan Hospital of Traditional Chinese Medicine,Zhoushan 316000,China;Department of Infectious Diseases,Zhoushan Hospital of Traditional Chinese Medicine,Zhoushan 316000,China
文献出处：
引用格式：
[1]XU Baogui;ZHENG Jiawen;TIAN Xiaoxiao;YUAN Falei;LIU Zhongliang;YANG Zuisu;DING Xianjun-.Antihepatofibrotic effect of Guizhifuling pill(桂枝茯苓丸)on carbon tetrachloride-induced liver fibrosis in mice)[J].中医杂志（英文版）,2022(05):715-722
A类：
Antihepatofibrotic,Guizhifuling,GZFL
B类：
pill,桂枝茯苓丸,carbon,tetrachloride,induced,liver,fibrosis,mice,OBJECTIVE,To,protective,effects,underlying,mechanism,CCl4,hepatic,METHODS,Male,ICR,intraperitoneally,administered,mixed,soybean,oil,Mice,that,underwent,were,orally,Using,hematoxylin,eosin,Masson,staining,examine,pathological,changes,tissue,Serum,biochemical,parameters,antioxidant,activity,proinflammatory,cytokines,was,assessed,Nuclear,kappaB,nuclear,erythroid,related,Nrf2,family,members,evaluated,blotting,RESULTS,Our,findings,indicated,could,effectively,suppress,progression,which,determined,improvement,function,reduction,collagen,deposition,treatment,also,decreased,level,increased,enzymes,Moreover,exerted,through,regulating,mediated,system,inhibiting,CONCLUSIONS,may,prevent,heme,oxygenase,signaling,pathways,thereby,highlighting,its,role,management
AB值：
0.51851
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