典型文献
Hepatoprotective effect of date palm fruit extract against doxorubicin intoxication in Wistar rats: In vivo and in silico studies
文献摘要：
Objective: To investigate the prophylactic efficacy of date palm fruit extract against doxorubicin-induced hepatotoxicity in Wistar albino rats. Methods: The rats were equally and randomly assigned to 6 groups: group 1 (untreated control), group 2 and 3 given daily oral administration of prophylactic aqueous extract of date palm fruit at 0.75 and 1.5 mg/kg body weight, respectively, and group 4, 5 and 6 intraperitoneally injected with doxorubicin at 15 mg/kg on day 30. Rats in group 5 and 6 received daily oral administration of aqueous extract of date palm fruit at 0.75 and 1.5 mg/kg body weight, respectively, for 30 d. The phytochemicals identified by GC-MS analysis were analyzed using in silico study. Antioxidant enzymes, liver enzymatic, biochemical parameters and histopathological analysis were determined to evaluate hepatoprotective activity of date extract. Results: Aqueous extract of date palm fruit significantly mitigated doxorubicin-induced changes in activities of liver enzymes, reduced reactive oxygen species levels, and suppressed lipid peroxidation and DNA damage. Moreover, aqueous extract of date palm fruit reduced doxorubicin-induced hepatic lesions. Molecular docking studies showed that most compounds of aqueous extract of date palm fruit identified via GC-MS had good interaction with proteins of human pregnane X receptor, oxygenase-1, and CYP2C9. Conclusions: The aqueous extract of date palm fruit mitigates doxorubicin-mediated DNA damage and hepatotoxicity, and restores normal liver function and may be a promising agent against the deleterious effects of doxorubicin.
文献关键词：
中图分类号：
作者姓名：
Ahmed M.Fatani;Othman A.S.Baothman;Lobna S Shash;Huda A.Abuaraki;Mustafa A Zeyadi;Salman B.Hosawi;Hisham N.Altayb;Mohamed K.Abo-Golayel
作者机构：
Biochemistry Department,Faculty of Science,King Abdulaziz University,Jeddah,Saudi Arabia;Microbial Toxicology&Natural Products Center,Faculty of Science,King Abdulaziz University,Jeddah,Saudi Arabia;Pathology Department,Faculty of Medicine,Ain Shams University,Cairo,Egypt;Laboratory Animal Unit,King Fahad Medical Research Centre,King Abdulaziz University,Jeddah,Saudi Arabia;Ain Shams University Research Institute,Ain Shams University Hospitals,Ain Shams University,Cairo,Egypt
文献出处：
引用格式：
[1]Ahmed M.Fatani;Othman A.S.Baothman;Lobna S Shash;Huda A.Abuaraki;Mustafa A Zeyadi;Salman B.Hosawi;Hisham N.Altayb;Mohamed K.Abo-Golayel-.Hepatoprotective effect of date palm fruit extract against doxorubicin intoxication in Wistar rats: In vivo and in silico studies)[J].亚太热带生物医学杂志（英文版）,2022(08):357-366
A类：
Hepatoprotective
B类：
date,palm,fruit,extract,against,doxorubicin,intoxication,Wistar,rats,In,vivo,silico,studies,Objective,To,investigate,prophylactic,efficacy,induced,hepatotoxicity,albino,Methods,were,equally,randomly,assigned,groups,untreated,control,given,daily,oral,administration,aqueous,body,weight,respectively,intraperitoneally,injected,day,Rats,received,phytochemicals,identified,by,analysis,analyzed,using,study,Antioxidant,enzymes,liver,enzymatic,biochemical,parameters,histopathological,determined,evaluate,hepatoprotective,activity,Results,Aqueous,significantly,mitigated,changes,activities,reduced,reactive,species,levels,suppressed,lipid,peroxidation,damage,Moreover,hepatic,lesions,Molecular,docking,showed,that,most,compounds,via,had,good,interaction,proteins,human,pregnane,receptor,oxygenase,CYP2C9,Conclusions,mitigates,mediated,restores,normal,function,may,be,promising,agent,deleterious,effects
AB值：
0.514104
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