典型文献
The neuroprotective effect of walnut-derived peptides against glutamate-induced damage in PC12 cells: mechanism and bioavailability
文献摘要：
In our previous study, defatted walnut meal hydrolysate (DWMH) could attenuate D-galactose-induced acute memory deficits in vivo, and six potent active peptides including WSREEQ, WSREEQE, WSREEQEREE, ADIYTE, ADIYTEEAG and ADIYTEEAGR were identified. The aim of this study was to investigate the possible mechanism underlying their neuroprotective effects on glutamate-induced apoptosis in PC12 cells and their digestive stability. Results showed that all these peptides could attenuate the reduction of cell viability caused by glutamate in PC12 cells, especially WSREEQEREE and ADIYTEEAGR. The addition of Arg residue in WSREEQEREE and ADIYTEEAGR might be the potential reason for their stronger protective effects. Additionally, these two peptides possibly protected PC12 cells against glutamate-induced apoptosis via activating intracellular antioxidant defence (superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)) through Kelch-like ECH-associated protein 1 (Keap1) inhibition, inhibiting ROS production, Ca2+ influx and mitochondrial membrane potential (MMP) collapse as well as regulating the expression of apoptosis-related proteins (Bax and Bcl-2). This might be due to the presence of Trp, Tyr and Arg in these two peptides. However, encapsulation of WSREEQEREE and ADIYTEEAGR should be considered based on their digestive sensibility during in vitro gastrointestinal digestion.
文献关键词：
中图分类号：
作者姓名：
Shuguang Wang;Lin Zheng;Tiantian Zhao;Qi Zhang;Guowan Su;Mouming Zhao
作者机构：
School of Food Science and Engineering,South China University of Technology,Guangzhou 510640,China;Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center,Guangzhou 510650,China;Guangdong Huapeptides Biotechnology Co.,Ltd.,Zhaoqing 526000,China
文献出处：
引用格式：
[1]Shuguang Wang;Lin Zheng;Tiantian Zhao;Qi Zhang;Guowan Su;Mouming Zhao-.The neuroprotective effect of walnut-derived peptides against glutamate-induced damage in PC12 cells: mechanism and bioavailability)[J].食品科学与人类健康（英文）,2022(04):933-942
A类：
WSREEQ,WSREEQE,WSREEQEREE,ADIYTE,ADIYTEEAG,ADIYTEEAGR
B类：
neuroprotective,walnut,derived,peptides,against,glutamate,induced,damage,PC12,cells,mechanism,bioavailability,In,our,previous,study,defatted,meal,hydrolysate,DWMH,could,attenuate,galactose,acute,memory,deficits,vivo,six,active,including,were,identified,aim,this,was,investigate,possible,underlying,their,effects,apoptosis,digestive,stability,Results,showed,that,these,reduction,viability,caused,by,especially,addition,Arg,residue,might,be,potential,reason,stronger,Additionally,two,possibly,protected,activating,intracellular,antioxidant,defence,superoxide,dismutase,glutathione,peroxidase,GSH,Px,through,Kelch,like,ECH,associated,Keap1,inhibition,inhibiting,ROS,production,Ca2+,influx,mitochondrial,membrane,MMP,collapse,well,regulating,expression,related,proteins,Bax,Bcl,This,presence,Trp,Tyr,However,encapsulation,should,considered,sensibility,during,vitro,gastrointestinal,digestion
AB值：
0.554743
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