典型文献
Analgesic-like activity of perillyl acetate: In vivo and in silico studies
文献摘要:
Objective: To evaluate the antinociceptive activity of perillyl acetate in mice and in silico simulations. Methods: The vehicle, perillyl acetate (100, 150 and/or 200 mg/kg, i.p.), diazepam (2 mg/kg, i.p.) or morphine (6 mg/kg, i.p.) was administered to mice, respectively. Rotarod test, acetic acid-induced abdominal writhing, formalin-induced nociception, hot plate test, and tail-flick test were performed. Opioid receptors-involvement in perillyl acetate antinociceptive effect was also investigated. Results: Perillyl acetate did not affect the motor coordination of mice. However, it reduced the number of acetic acid-induced abdominal twitches and licking times in the formalin test. There was an increase of latency time in the tail-flick test of 30 and 60 minutes. Pretreatment with naloxone reversed the antinociceptive effect of perillyl acetate (200 mg/kg). In silico analysis demonstrated that perillyl acetate could bind to μ-opioid receptors. Conclusions: Perillyl acetate has antinociceptive effect at the spinal level in animal nociception models, without affecting the locomotor integrity and possibly through μ-opioid receptors. In silico studies have suggested that perillyl acetate can act as a μ-opioid receptor agonist.
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中图分类号:
作者姓名:
Renan Braga;Humberto Andrade;Ryldene Cruz;Mayara Maia;Carolina Lima;Anderson Santos;André Miranda;Allana Duarte;Marcus Scotti;Reinaldo Almeida;Dami?o Sousa
作者机构:
Postgraduate Program in Natural and Synthetic Bioactive Products,Federal University of Paraíba,58051-970,Jo?o Pessoa,PB,Brazil;Research Institute for Drugs and Medicines,Federal University of Paraíba,CP 5009,Jo?o Pessoa,58051-900,PB,Brazil;Department of Pharmaceutical Sciences,Federal University of Paraíba,58051-970,Jo?o Pessoa,PB,Brazil
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引用格式:
[1]Renan Braga;Humberto Andrade;Ryldene Cruz;Mayara Maia;Carolina Lima;Anderson Santos;André Miranda;Allana Duarte;Marcus Scotti;Reinaldo Almeida;Dami?o Sousa-.Analgesic-like activity of perillyl acetate: In vivo and in silico studies)[J].亚太热带生物医学杂志(英文版),2022(04):156-163
A类:
perillyl,Rotarod,flick,Opioid,Perillyl,twitches,licking,naloxone
B类:
Analgesic,like,activity,acetate,In,vivo,silico,studies,Objective,To,evaluate,antinociceptive,mice,simulations,Methods,vehicle,diazepam,morphine,was,administered,respectively,test,acetic,acid,induced,abdominal,writhing,formalin,nociception,hot,plate,tail,were,performed,receptors,involvement,effect,also,investigated,Results,did,not,coordination,However,reduced,number,times,There,increase,latency,minutes,Pretreatment,reversed,analysis,demonstrated,that,could,bind,opioid,Conclusions,has,spinal,level,animal,models,without,affecting,locomotor,integrity,possibly,through,have,suggested,can,agonist
AB值:
0.433454
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