FAILED
首站-论文投稿智能助手
典型文献
Analgesic-like activity of perillyl acetate: In vivo and in silico studies
文献摘要:
Objective: To evaluate the antinociceptive activity of perillyl acetate in mice and in silico simulations. Methods: The vehicle, perillyl acetate (100, 150 and/or 200 mg/kg, i.p.), diazepam (2 mg/kg, i.p.) or morphine (6 mg/kg, i.p.) was administered to mice, respectively. Rotarod test, acetic acid-induced abdominal writhing, formalin-induced nociception, hot plate test, and tail-flick test were performed. Opioid receptors-involvement in perillyl acetate antinociceptive effect was also investigated. Results: Perillyl acetate did not affect the motor coordination of mice. However, it reduced the number of acetic acid-induced abdominal twitches and licking times in the formalin test. There was an increase of latency time in the tail-flick test of 30 and 60 minutes. Pretreatment with naloxone reversed the antinociceptive effect of perillyl acetate (200 mg/kg). In silico analysis demonstrated that perillyl acetate could bind to μ-opioid receptors. Conclusions: Perillyl acetate has antinociceptive effect at the spinal level in animal nociception models, without affecting the locomotor integrity and possibly through μ-opioid receptors. In silico studies have suggested that perillyl acetate can act as a μ-opioid receptor agonist.
文献关键词:
作者姓名:
Renan Braga;Humberto Andrade;Ryldene Cruz;Mayara Maia;Carolina Lima;Anderson Santos;André Miranda;Allana Duarte;Marcus Scotti;Reinaldo Almeida;Dami?o Sousa
作者机构:
Postgraduate Program in Natural and Synthetic Bioactive Products,Federal University of Paraíba,58051-970,Jo?o Pessoa,PB,Brazil;Research Institute for Drugs and Medicines,Federal University of Paraíba,CP 5009,Jo?o Pessoa,58051-900,PB,Brazil;Department of Pharmaceutical Sciences,Federal University of Paraíba,58051-970,Jo?o Pessoa,PB,Brazil
引用格式:
[1]Renan Braga;Humberto Andrade;Ryldene Cruz;Mayara Maia;Carolina Lima;Anderson Santos;André Miranda;Allana Duarte;Marcus Scotti;Reinaldo Almeida;Dami?o Sousa-.Analgesic-like activity of perillyl acetate: In vivo and in silico studies)[J].亚太热带生物医学杂志(英文版),2022(04):156-163
A类:
perillyl,Rotarod,flick,Opioid,Perillyl,twitches,licking,naloxone
B类:
Analgesic,like,activity,acetate,In,vivo,silico,studies,Objective,To,evaluate,antinociceptive,mice,simulations,Methods,vehicle,diazepam,morphine,was,administered,respectively,test,acetic,acid,induced,abdominal,writhing,formalin,nociception,hot,plate,tail,were,performed,receptors,involvement,effect,also,investigated,Results,did,not,coordination,However,reduced,number,times,There,increase,latency,minutes,Pretreatment,reversed,analysis,demonstrated,that,could,bind,opioid,Conclusions,has,spinal,level,animal,models,without,affecting,locomotor,integrity,possibly,through,have,suggested,can,agonist
AB值:
0.433454
相似文献
Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells
Leyi Yao;Qian Zhao;Ding Yan;Ziying Lei;Yali Hao;Jinghong Chen;Qian Xue;Xiaofen Li;Qingtian Huang;Daolin Tang;Q.Ping Dou;Xin Chen;Jinbao Liu-Affiliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou 510095,China;Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation,State Key Laboratory of Respiratory Disease,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China;Institute of Digestive Disease of Guangzhou Medical University,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital,Qingyuan 511518,China;School of Public Health,Guangzhou Medical University,Guangzhou,511436,China;Department of Surgery,UT Southwestern Medical Center,Dallas,TX 75390,USA;Barbara Ann Karmanos Cancer Institute and Departments of Oncology,Pharmacology&Pathology,School of Medicine,Wayne State University,Detroit,MI 48201,USA
Taxifolin attenuates inflammation via suppressing MAPK signal pathway in vitro and in silico analysis
Xingyan Zhang;Xiaoyan Lian;Huling Li;Wenjing Zhao;Xin Li;Fujun Zhou;Yutong Zhou;Tao Cui;Yuli Wang;Changxiao Liu-Key Laboratory of Quality-marker of Traditional Chinese Medicines,Tianjin Institute of Pharmaceutical Research Co.,Ltd.,Tianjin 300462,China;Center for Drug Evaluation,National Medical Products Administration,Beijing 100022,China;Department of Pharmacology,Tianjin Medical University,Tianjin 300070,China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research Co.,Ltd.,Tianjin 300462,China;Key Laboratory of Systems Bioengineering(Ministry of Education),School of Chemistry Engineering and Technology,Tianjin University,Tianjin 300072,China;Pharmaceuticai Armaceuticai DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Researchinstitute,Tianjin 300457,China;Tianjin Key Laboratory of Quality Control in Chinese Medicine,Tianjin 300457,China;Research Unit for Drug Metabolism,Chinese Academy of Medical Sciences,Beijing 100730,China
Pharmacological efficacy of the traditional Chinese medicinal formula Kun-Tai-1A in the treatment of letrozole-induced polycystic ovary syndrome
Leanne Lee Leung;Jing Xie;Ya-Cun Chen;Kar-Ho Lam;Hei Wan;Su-Lan Yu;Tzi-Bun Ng;George Pak-Heng Leung;Jin Yu;Ren-Min Yao;Shu-Jia Sun;Sydney Chi-Wai Tang;Hai-Yong Chen;Jia Zhao;Zhang-Jin Zhang;Calvin Kai-Fai Lee;Kalin Yan-Bo Zhang;Li-Xing Lao;Yun Feng;Xiang Lin;Wei Meng-School of Chinese Medicine,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China;School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong 999077,China;Department of Pharmacology and Pharmacy,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China;Workstation for Training and Research(Hong Kong Branch),Distinguished Professor Yu Jin Gynaecology of Chinese Medicine&Integrative Medicine,Hong Kong 999077,China;Shanghai Taikuntang Chinese Medicine Hospital,Shanghai 200023,China;Department of Medicine,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China;Department of Obstetrics and Gynaecology,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China;Virginia University of Integrative Medicine,Virginia 22031,USA;Department of Ophthalmology,Peking University Third Hospital,Beijing 100191,China;Workstation of Zhu Nansun,National Master of Chinese Medicine,Hong Kong Branch of Zhu's School of Gynaecology of Chinese Medicine from Shanghai,Hong Kong 999077,China
机标中图分类号,由域田数据科技根据网络公开资料自动分析生成,仅供学习研究参考。