典型文献
Analgesic alkaloids from Urticae Fissae Herba
文献摘要：
Objective:To investigate the analgesic substances in the aerial part of Urtica fissa(Urticae Fissae Herba),commonly used for rheumatoid and rheumatism arthritis.Methods:The analgesic constituents were isolated with the active guidance of hot plate and acetic acid writhing models,and identified by comprehensive spectroscopic analysis.Results:Thirteen alkaloids(1-13),two lignans(14,15),and three amides(16-18)were isolated from the active fractions.Among them,compound 1 was a new alkaloid,and compound 6 was a new natural prod-uct.The activity evaluation in vivo indicated that various pyrrole alkaloids(1,3,6,and 12)possessed sig-nificant analgesic activities,they could significantly inhibit the mice pain response induced by acetic acid and hot plate at the dosage of 2 mg/kg BW.Conclusion:The study revealed that the pyrrole alkaloids played important roles in the analgesic activi-ties of Urticae Fissae Herba.
文献关键词：
中图分类号：
作者姓名：
Xiaoru Feng;Peijun Ju;Yan Chen;Xiaobo Li;Mengyue Wang
作者机构：
School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China;Shanghai Key Laboratory of Psychotic Disorders,Shanghai 200230,China
文献出处：
引用格式：
[1]Xiaoru Feng;Peijun Ju;Yan Chen;Xiaobo Li;Mengyue Wang-.Analgesic alkaloids from Urticae Fissae Herba)[J].中草药（英文版）,2022(01):125-129
A类：
Urticae,Fissae
B类：
Analgesic,alkaloids,from,Herba,Objective,To,investigate,analgesic,substances,aerial,part,fissa,commonly,used,rheumatoid,rheumatism,arthritis,Methods,constituents,were,isolated,active,guidance,hot,plate,acetic,acid,writhing,models,identified,by,comprehensive,spectroscopic,analysis,Results,Thirteen,two,lignans,three,amides,fractions,Among,them,compound,was,new,natural,prod,uct,activity,evaluation,vivo,indicated,that,various,pyrrole,possessed,activities,they,could,significantly,inhibit,mice,pain,response,induced,dosage,BW,Conclusion,study,revealed,played,important,roles
AB值：
0.569998
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
