Objective: To investigate hypertriglyceridemia and hepatomegaly caused by Schisandrae Sphenantherae Fructus (FSS) and Schisandra chinensis Fructus (FSC) oils in mice.Methods: Mice were orally administered a single dose of Schisandrae Fructus oils. Serum and hepatic triglyceride (TG), triglyceride transfer protein (TTP), apolipoprotein B48 (Apo B48), very-low-density lipoprotein (VLDL), hepatocyte growth factor (HGF), alanine aminotransfease (ALT) and liver index were measured at 6-120 h post-dosing. Results: FSS and FSC oil caused time and dose-dependent increases in serum and hepatic TG levels, with maximum increases in the liver (by 297％ and 340％) at 12 h post-dosing and serum (244％ and 439％) at 24-h post-dosing, respectively. Schisandrae Fructus oil treatments also elevated the levels of serum TTP by 51％ and 63％, Apo B48 by 152％ and 425％, and VLDL by 67％ and 38％ in mice, respectively. FSS and FSC oil treatments also increased liver mass by 53％ and 55％ and HGF by 106％ and 174％, but lowered serum ALT activity by 38％ and 22％, respectively. Fenofibrate pre/co-treatment attenuated the FSS and FSC oil-induced elevation in serum TG levels by 41％ and 49％ at 48 h post-dosing, respectively, but increased hepatic TG contents (by 38％ and 33％, respectively) at 12 h post-dosing. Conclusions: Our findings provide evidence to support the establishment of a novel mouse model of hypertriglyceridemia by oral administration of FSS oil (mainly increasing endogenous TG) and FSC oil (mainly elevating exogenous TG).

Si-Yuan Pan;Xue-Lan Song;Zhao-Heng Lin;Qing Yu;Yi Zhang;Hai-Chuan Tai;Gan Luo;Xiao-Yan Wang;Pei-Li Zhu;Nan Sun;Zhu-Sheng Chu;Zhi-Ling Yu;Kam-Ming Ko

School of Traditional Dai-Thai Medicine,West Yunnan University of Applied Sciences,Jinghong,Yunnan,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing,China;Department of Biology,Hong Kong Baptist University,Hong Kong,China;School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,China;Division of Life Science,Hong Kong University of Science&Technology,Hong Kong,China

亚太热带生物医学杂志（英文版）

[1]Si-Yuan Pan;Xue-Lan Song;Zhao-Heng Lin;Qing Yu;Yi Zhang;Hai-Chuan Tai;Gan Luo;Xiao-Yan Wang;Pei-Li Zhu;Nan Sun;Zhu-Sheng Chu;Zhi-Ling Yu;Kam-Ming Ko-.Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice)[J].亚太热带生物医学杂志（英文版）,2022(02):59-68

Schisandrae,hepatomegaly,Sphenantherae,aminotransfease,Fenofibrate

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