典型文献
Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice
文献摘要：
Accumulating evidence revealed that some probiotics regulated lipid metabolism and alleviated diet-induced non-alcoholic fatty liver disease (NAFLD). This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism, and suppressed microbial dysbiosis in high-fat diet (HFD)-fed mice. Results showed that oral administration of L. plantarum Q16 improved serum and hepatic lipid profile. Protein analysis showed that L. plantarum Q16 could reduce hepatic lipid content by reducing the expression of FAS, ACC, SCD-1, Srebp-1c and ATGL, but increasing expression levels of CPT-1α, PPAR-α and ATGL. Meanwhile, L. plantarum Q16 also improved hepatic energy metabolism by regulating FGF21/adiponectin/AMPKα/PGC-1α signaling pathway. Metagenomic analysis also discovered that L. plantarum Q16 increased species diversity and richness of intestinal microbiota, promoted proliferation of beneficial commensals and suppressed the growth of endotoxin-producing microorganisms in the colon of HFD-fed mice. Overall, L. plantarum Q16 protected against HFD-induced NAFLD by improving hepatic profile and regulating colonic microbiota composition.
文献关键词：
中图分类号：
作者姓名：
Chao Tang;Weiwei Zhou;Mengyuan Shan;Zhaoxin Lu;Yingjian Lu
作者机构：
College of Food Science and Technology,Nanjing Agricultural University,Nanjing 210095,China;College of Food Science and Engineering,Nanjing University of Finance and Economics,Nanjing 210023,China
文献出处：
引用格式：
[1]Chao Tang;Weiwei Zhou;Mengyuan Shan;Zhaoxin Lu;Yingjian Lu-.Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice)[J].食品科学与人类健康（英文）,2022(05):1428-1439
A类：
Yogurt,Q16,yogurt
B类：
derived,Lactobacillus,plantarum,alleviated,high,diet,induced,alcoholic,fatty,liver,disease,mice,Accumulating,evidence,revealed,that,some,probiotics,regulated,lipid,metabolism,NAFLD,This,study,mainly,explored,whether,modulated,energy,suppressed,microbial,dysbiosis,HFD,fed,Results,showed,oral,administration,improved,serum,hepatic,profile,Protein,analysis,could,reduce,content,by,reducing,expression,FAS,ACC,SCD,Srebp,1c,ATGL,but,increasing,levels,CPT,PPAR,Meanwhile,also,regulating,FGF21,adiponectin,AMPK,PGC,signaling,pathway,Metagenomic,discovered,increased,species,diversity,richness,intestinal,microbiota,promoted,proliferation,beneficial,commensals,growth,endotoxin,producing,microorganisms,Overall,protected,against,improving,colonic,composition
AB值：
0.54463
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