Objective::Cardiac damage is commonly reported in patients with coronavirus disease 2019 (COVID-19) but its prevalence and impact on the long-term survival of patients remain uncertain. This study aimed to explore the prevalence of myocardial injury and assess its prognostic value in patients with COVID-19.Methods::A single-center, retrospective cohort study was performed at the Affiliated Hospital of Jianghan University. Data from 766 patients with confirmed COVID-19 who were hospitalized from December 27, 2019 to April 25, 2020 were collected. Demographic, clinical, laboratory, electrocardiogram, treatment data and all-cause mortality during follow-up were collected and analyzed.Results::Of the 766 patients with moderate to critically ill COVID-19, 86 (11.2%) died after a mean follow-up of 72.8 days. Myocardial injury occurred in 94 (12.3%) patients. The mortality rate was 64.9% (61/94) and 3.7% (25/672) in patients with and without myocardial injury, respectively. Cox regression showed that myocardial injury was an independent risk factor for mortality (hazard ratio: 8.76, 95% confidence interval: 4.76-16.11, P < 0.001). Of the 90 patients with myocardial injury with electrocardiogram results, sinus tachycardia was present in 29, bundle branch block in 26, low voltage in 10, and abnormal T-wave in 53. Conclusions::COVID-19 not only involves pneumonia but also cardiac damage. Myocardial injury is a common complication and an independent risk factor for mortality in COVID-19 patients.

Coronavirus;COVID-19;Mortality;Myocardial injury

Li Fajiu;Zhu Xijie;Zhu Ziyang;Yang Yinjian;Tian Zhuang;Wang Duolao;Chen Shi;Gao Xiaoyan;Xu Yalin;Zhang Bo;Yu Wei;Liu Min;Xu Xiqi;Li Chenghong;Zhang Shuyang

Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China;Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China;Department of Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China;Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, Merseyside L3 5QA, United Kingdom;Department of Geriatrics, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China;Department of Cardiology, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China

心血管病探索（英文）

[1]Li Fajiu;Zhu Xijie;Zhu Ziyang;Yang Yinjian;Tian Zhuang;Wang Duolao;Chen Shi;Gao Xiaoyan;Xu Yalin;Zhang Bo;Yu Wei;Liu Min;Xu Xiqi;Li Chenghong;Zhang Shuyang-.Non-Ischemic, Non-Hypoxic Myocardial Injury, and Long-Term Mortality in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study)[J].心血管病探索（英文）,2022(02):77-82

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