典型文献
Centranthera grandiflore alleviates alcohol-induced oxidative stress and cell apoptosis
文献摘要：
Alcohol liver disease(ALD)has become a global threat to human health.It is associated with a wide range of liver dis-eases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cancer and even death.Centranthera gran-diflora is a traditional Chinese medicinal herb commonly used to treat ALD,but no research about its mechanism is available.This study evaluated the hepatoprotective effect and mechanism of C.grandiflora against alcohol-induced liver injury in mice.We found that the ethanol extracts of C.grandiflora(CgW)alleviated the alcohol-induced liver injury,enhanced the levels of antioxidant en-zymes,and reduced the amount of lipid peroxides.CgW also affected cell apoptosis by inhibiting the activity of Bax,cleaved-caspase 3 and cleaved-caspase 9,and increasing the activity of Bcl-2.In conclusion,the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first time.This study suggested that C.grandiflora is a prom-ising herbal medicine for ALD treatment.
文献关键词：
中图分类号：
作者姓名：
GAO Xin-Mei;DONG Wen-Han;XIA Chun-Lei;MA Zhuo-Yi;WANG Ying;SARRA Setrerrahmane;XU Han-Mei;QI Wei-Yan
作者机构：
The Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation,Jiangsu Province,State Key Laborat-ory of Natural Medicines,Ministry of Education,Department of Marine Pharmacy,China Pharmaceutical University,Nanjing 211198,China;Science and Technology Administration Department of Yunnan Agricultural University,Yunnan 650205,China;Nanjing Anji Biotechnology Co.,Ltd.,Nanjing 210033,China
文献出处：
引用格式：
[1]GAO Xin-Mei;DONG Wen-Han;XIA Chun-Lei;MA Zhuo-Yi;WANG Ying;SARRA Setrerrahmane;XU Han-Mei;QI Wei-Yan-.Centranthera grandiflore alleviates alcohol-induced oxidative stress and cell apoptosis)[J].中国天然药物,2022(08):572-579
A类：
Centranthera,grandiflore,diflora,CgW
B类：
alleviates,alcohol,induced,oxidative,stress,cell,apoptosis,Alcohol,liver,disease,ALD,has,become,global,threat,human,health,It,associated,wide,range,eases,including,fatty,steatosis,fibrosis,cirrhosis,finally,leads,cancer,even,death,traditional,Chinese,medicinal,commonly,used,but,research,about,its,mechanism,available,This,study,evaluated,hepatoprotective,grandiflora,against,injury,mice,We,found,that,ethanol,extracts,alleviated,enhanced,levels,antioxidant,zymes,reduced,amount,lipid,peroxides,also,affected,by,inhibiting,activity,Bax,cleaved,caspase,increasing,Bcl,In,conclusion,results,showed,effectively,improve,through,alleviating,first,suggested,prom,ising,herbal,medicine,treatment
AB值：
0.560836
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