典型文献
Quality evaluation of Pinelliae Rhizoma using network pharmacology and multi-component quantitative analysis
文献摘要：
Background: Pinelliae Rhizoma (Banxia) is a valuable traditional Chinese medicine, and its quality issues are related to the safety and effectiveness of the medicine. Several pharmacological experiments have shown that Pinelliae Rhizoma has anti-inflammatory activity, but the specific chemical components remain unclear. Methods: In the present study, network pharmacology was used to analyze the potential active ingredients and molecular mechanisms of Pinelliae Rhizoma's anti-inflammatory activity. A new approach to simultaneously determine eight components using high performance liquid chromatography –photo-diode array was developed to evaluate the quality of Pinelliae Rhizoma and different processed Pinelliae Rhizoma products. Results: Twelve active ingredients were identified from Pinelliae Rhizoma, and β-sitosterol may have a greater effect than the other active ingredients. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed the main pathways associated with Pinelliae Rhizoma's mechanism for treating inflammation. Additionally, the β-sitosterol content in different processed Pinelliae Rhizoma products decreased significantly, and the level of five nucleosides in Pinelliae Rhizoma was significantly higher than that of the processed Pinelliae Rhizoma products. The 6-gingerol content was detected in eight Pinelliae Rhizoma Praeparatum cum Zingibere et Alumine batches with different origins, and liquiritin and liquiritigenin levels were detected in eight batches of Pinelliae Rhizoma Praeparatum with different origins. Conclusion: Pinelliae Rhizoma quality was affected by different regions and different processing methods, and this research provides a reference for Pinelliae Rhizoma quality evaluation.
文献关键词：
中图分类号：
作者姓名：
Xin-Yang Li;Di Liang;Xue-Qian Zhang;Xiao-Huan Li;Miao Sha;Xue-Ming Zhang;Lan-Ping Guo;Wen-Yuan Gao;Xia Li
作者机构：
Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300193,China;Key Laboratory of Modern Chinese Medicine Resources Research Enterprises,Tianjin 300402,China;National Resource Center for Chinese Materia Medica,Academy of Chinese Medical Sciences,Beijing 100700,China;College of Pharmacy,Qinghai Minzu University,Qinghai 810007,China
文献出处：
引用格式：
[1]Xin-Yang Li;Di Liang;Xue-Qian Zhang;Xiao-Huan Li;Miao Sha;Xue-Ming Zhang;Lan-Ping Guo;Wen-Yuan Gao;Xia Li-.Quality evaluation of Pinelliae Rhizoma using network pharmacology and multi-component quantitative analysis)[J].传统医学研究（英文版）,2022(04):17-26
A类：
Pinelliae,gingerol,Praeparatum,Zingibere,Alumine
B类：
Quality,evaluation,Rhizoma,using,network,pharmacology,multi,quantitative,analysis,Background,Banxia,valuable,traditional,Chinese,medicine,its,quality,issues,are,related,safety,effectiveness,Several,pharmacological,experiments,have,shown,that,has,inflammatory,activity,but,specific,chemical,components,remain,unclear,Methods,In,present,study,was,used,analyze,potential,active,ingredients,molecular,mechanisms,new,approach,simultaneously,determine,eight,performance,liquid,chromatography,photo,diode,array,developed,evaluate,different,processed,products,Results,Twelve,were,identified,from,sitosterol,may,greater,than,other,Ontology,Kyoto,Encyclopedia,Genes,Genomes,enrichment,analyses,revealed,pathways,associated,treating,inflammation,Additionally,content,decreased,significantly,five,nucleosides,higher,detected,cum,batches,origins,liquiritin,liquiritigenin,levels,Conclusion,affected,by,regions,processing,methods,this,research,provides,reference
AB值：
0.454542
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