Objective:Granules of herbal extracts are a popular medicinal preparation consumed in traditional Chinese medicine clinical practice.However,their quality and efficacy evaluation are lacking.This study aimed to compare the quality and anti-oxidant activity of Dan Shen(Salvia miltiorrhiza Radix&Rhizoma)granule extracts with their herbal extracts.Methods:Chromatographic method was used to determine the content of 7 marker compounds in the water extracts of the herb compared to that of 12 granule extracts.Agglomerative hierarchical clustering(AHC)and principal component analysis(PCA)distinguished the herbal and granule extracts based on the content of the marker compounds.The antioxidant activities of herbal and granule extracts were evaluated by 2,2'-azino-bis(3-ethylbenz-thiazoline-6-sulfonic acid)(ABTS),organic chemical compound 2,2-diphenyl-1-picrylhydrazyl(DPPH)and ferric ion reducing antioxidant power(FRAP)assays.Results:The herbal extracts group showed significantly higher contents of salvianolic acid B,sodium danshensu and cryptotanshinone compared with that of the granule group.This corresponded to significantly higher ABTS,DPPH and FRAP(P＜.05)activities of the herbal extracts.The AHC and PCA analysis distinguished granule extracts from most herbal extracts predominantly by the content of sal-vianolic acid B.Conclusion:The results confirm the need for the assessment of granule products so that healthcare practitioners and consumers are better informed of their quality and efficacy.

Xian Zhou;Valentina Razmovski-Naumovski;Raynold Mendoza;John Truong;Kelvin Chan

NICM Health Research Institute,Western Sydney University,Westmead,2145,Australia;South West Sydney Clinical Campuses,Faculty of Medicine&Health,University of New South Wales,Sydney,NSW,2170,Australia;School of Pharmacy and Biomolecular Sciences,Liverpool John Moores University,Liverpool,L3 3AF,UK

中医科学杂志（英文）

[1]Xian Zhou;Valentina Razmovski-Naumovski;Raynold Mendoza;John Truong;Kelvin Chan-.A comparative study of Salvia miltiorrhiza Radix&Rhizoma raw material and granule products using chromatographic analysis and antioxidant activity)[J].中医科学杂志（英文）,2022(03):311-320

ethylbenz,thiazoline,danshensu,vianolic

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