典型文献
Epidemiological characteristics of central nervous system tumors in children: a 5-year review of 3180 cases from Beijing Tiantan Hospital
文献摘要：
Background::To describe the epidemiological characteristics of central nervous system (CNS) tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital.Methods::From January 2015 to December 2019, 3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization (WHO) classification of tumors. Patients were 0 to 15 years old. We analyzed age-related gender preferences, tumor locations, and the histological grades of the tumors. In addition, the epidemiological characteristics of the five most common intracranial tumors were compared to the previous studies.Results::In this study, intracranial and spinal tumors account for 96.4% (3066) and 3.6% (114) of all tumors, with a preponderance of supratentorial tumors (57.9%). Among all pediatric patients, low-grade tumors comprise 67.1% (2 135). The integral gender ratio of males to females is 1.47: 1 and the average age of patients is 7.59 years old. The five most common intracranial tumors are craniopharyngioma (15.4%), medulloblastoma (14.3%), pilocytic astrocytoma (11.8%), diffuse astrocytoma (9.8%), and anaplastic ependymoma (4.8%).Conclusions::Due to the lack of national data on childhood brain tumors, we used a large nationally representative population sample based on the largest pediatric neurosurgery center in China. We analyzed the data of the past 5 years, reflecting the incidence of CNS tumors in Chinese children to a certain extent, and laying a data foundation for subsequent clinical studies.
文献关键词：
Epidemiology;Central nervous system tumors;Pediatric;World Health Organization classification
中图分类号：
作者姓名：
Liu Zhi-ming;Liao Chih-yi;Zhang Heng;Han Zhe;Wang Jun-mei;Ma Zhen-yu;Li Chun-de;Gong Jian;Liu Wei;Sun Tao;Tian Yong-ji
作者机构：
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;China National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Brain Tumor, Beijing, China;Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
文献出处：
引用格式：
[1]Liu Zhi-ming;Liao Chih-yi;Zhang Heng;Han Zhe;Wang Jun-mei;Ma Zhen-yu;Li Chun-de;Gong Jian;Liu Wei;Sun Tao;Tian Yong-ji-.Epidemiological characteristics of central nervous system tumors in children: a 5-year review of 3180 cases from Beijing Tiantan Hospital)[J].中华神经外科杂志（英文）,2022(03):188-194
A类：
craniopharyngioma,pilocytic,ependymoma
B类：
Epidemiological,characteristics,central,nervous,system,tumors,children,review,cases,from,Beijing,Tiantan,Hospital,Background,To,describe,epidemiological,CNS,neurosurgery,department,Methods,From,January,December,were,histopathologically,diagnosed,World,Health,Organization,WHO,classification,Patients,years,old,We,analyzed,related,gender,preferences,locations,histological,grades,In,addition,five,most,common,intracranial,compared,previous,studies,Results,this,study,spinal,account,preponderance,supratentorial,Among,pediatric,patients,low,comprise,integral,ratio,females,average,medulloblastoma,astrocytoma,diffuse,anaplastic,Conclusions,Due,lack,data,childhood,brain,used,nationally,representative,population,sample,largest,center,China,past,reflecting,incidence,Chinese,certain,extent,laying,foundation,subsequent,clinical,Epidemiology,Central,Pediatric
AB值：
0.5154
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