典型文献
New prenylated flavonoid glycosides derived from Epimedium wushanense by β-glucosidase hydrolysis and their testosterone production-promoting effects
文献摘要：
Six new prenylated flavonoid glycosides,including four new furan-flavonoid glycosides wushepimedoside A-D(1-4)and two new prenyl flavonoid derivatives wushepimedoside E-F(5-6),and one know analog epimedkoreside B(7)were isolated from biotransformation products of the aerial parts of Epimedium wushanense.Their structures were elucidated according to comprehensive analysis of HR-MS and NMR spectroscopic data,and the absolute configurations were assigned using experimental and calculated electronic circular dichroism(ECD)data.The regulatory activity of compounds 1-7 on the production of testosterone in primary rat Leydig cells were investigated,and 4 and 5 exhibited testosterone production-promoting activities.Molecular docking analysis sugges-ted that bioactive compounds 4 and 5 showed the stable binding with 3β-HSD and 4 also had good affinity with Cyp17A1,which sug-gested that these compounds may regulate testosterone production through stimulating the expression of the above two key proteins.
文献关键词：
中图分类号：
作者姓名：
SUN Xin-Guang;PANG Xu;LIANG Hai-Zhen;ZHANG Jie;WANG Bei;LI Qi;WANG Jie;CHEN Xiao-Juan;GUO Bao-Lin;MA Bai-Ping
作者机构：
Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine,Beijing 100850,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China
文献出处：
引用格式：
[1]SUN Xin-Guang;PANG Xu;LIANG Hai-Zhen;ZHANG Jie;WANG Bei;LI Qi;WANG Jie;CHEN Xiao-Juan;GUO Bao-Lin;MA Bai-Ping-.New prenylated flavonoid glycosides derived from Epimedium wushanense by β-glucosidase hydrolysis and their testosterone production-promoting effects)[J].中国天然药物,2022(09):712-720
A类：
prenylated,wushanense,wushepimedoside,prenyl,epimedkoreside,Cyp17A1
B类：
New,flavonoid,glycosides,derived,from,Epimedium,by,glucosidase,hydrolysis,their,testosterone,production,promoting,effects,Six,new,including,four,furan,two,derivatives,know,analog,were,isolated,biotransformation,products,aerial,parts,Their,structures,elucidated,according,comprehensive,analysis,NMR,spectroscopic,data,absolute,configurations,assigned,using,experimental,calculated,electronic,circular,dichroism,ECD,regulatory,activity,compounds,primary,Leydig,cells,investigated,exhibited,activities,Molecular,docking,sugges,that,bioactive,showed,stable,binding,HSD,also,had,good,affinity,which,gested,these,may,regulate,through,stimulating,expression,above,key,proteins
AB值：
0.572697
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
