Both tea polyphenols and selenium(Se)have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation,which make Se-enriched oolong tea a promising beverage as an anti-inflammatory diet.The aim of this study is to investigate the anti-inflammatory effects of Se-enriched oolong tea extract(Se-TE)and underlying mechanism in lipopolysaccharide(LPS)-induced RAW264.7 cells.Se-TE treatments(50 and 150 μg/mL)significantly suppressed the over-production of nitric oxide(NO)and prostaglandin E2(PGE2)in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2).Moreover,Se-TEs also effectively inhibited the productions of inflammatory cytokines,such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-1β(IL-1β).Furthermore,Se-TE could block mitogen-activated protein kinase(MAPK)and nuclear factor-kappa B(NF-kB)signaling pathways through the inhibition of the phosphorylation of key proteins(IκB-α,p65,p38,ERK,and JNK)and the translocation of the p65 subunit into the nucleus.Collectively,our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases.

Qi Wang;Juqing Huang;Yafeng Zheng;Xuefang Guan;Chenchun Lai;Huiying Gao;Chi-Tang Ho;Bin Lin

Institute of Agricultural Engineering,Fujian Academy of Agricultural Sciences,Fuzhou 350003,China;Fujian Key Laboratory of Agricultural Product(Food)Processing,Fuzhou 350003,China;College of Food Science,Fujian Agriculture and Forestry University,Fuzhou 350002,China;Department of Food Science,Rutgers University,New Brunswick,NJ 08901,USA

食品科学与人类健康（英文）

[1]Qi Wang;Juqing Huang;Yafeng Zheng;Xuefang Guan;Chenchun Lai;Huiying Gao;Chi-Tang Ho;Bin Lin-.Selenium-enriched oolong tea(Camellia sinensis)extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages)[J].食品科学与人类健康（英文）,2022(03):635-642

Selenium,enriched,oolong,tea,Camellia,sinensis,extract,exerts,anti,inflammatory,potential,via,targeting,MAPK,pathways,macrophages,Both,polyphenols,selenium,have,been,suggested,health,benefits,regulatory,capacities,chronic,inflammation,which,make,promising,beverage,diet,aim,this,study,investigate,effects,underlying,mechanism,lipopolysaccharide,LPS,induced,RAW264,cells,treatments,significantly,suppressed,nitric,oxide,prostaglandin,PGE2,stimulated,downregulating,expression,synthase,iNOS,cyclooxygenase,COX,Moreover,TEs,also,effectively,inhibited,productions,cytokines,such,tumor,necrosis,interleukin,Furthermore,could,block,mitogen,activated,kinase,nuclear,kappa,kB,signaling,through,inhibition,phosphorylation,key,proteins,p65,p38,ERK,JNK,translocation,subunit,into,nucleus,Collectively,our,results,indicated,that,may,used,novel,ingredient,development,various,foods,prevention,related,diseases

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