典型文献
Protective efficacy of dark chocolate in letrozole-induced ovary toxicity model rats:hormonal,biochemical,and histopathological investigation
文献摘要：
OBJECTIVE:To assess the protective effect of dark chocolate(DC)on the letrozole-induced rat model of polycystic ovary syndrome(PCOS).METHODS:In this experimental study,32 female Wistar rats,weighing(200±20)g,were randomly categorized into 4 groups including control,letrozole(1 mg·kg-1·d-1),metformin(500 mg·kg-1·d-1)along with letrozole,and DC(500 mg·kg-1·d-1)along with letrozole for 28 d by oral gavage.Twenty-four hours after the last supplementation,direct blood sampling was taken from the heart to obtain blood serum for evaluation of sex hormones and gonadotropins,oxidative parameters,inflammatory cytokines,and ovarian tissue was examined for histology.RESULTS:The DC treatment significantly improved PCOS signs,as demonstrated by the significant restoration of ovarian morphology and physiological functions as compared with the letrozole group.DC treatment also decreased ovarian interleukin-1β and tumor necrosis factor-α levels and improved total oxidative/antioxidative status as compared with the letrozole group.CONCLUSIONS:Treating the animals with DC could alleviate the PCOS symptoms and reduced the toxic effects of letrozole in the ovary.This effect may mediate through antioxidant and antiinflammatory properties.
文献关键词：
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作者姓名：
Naser Mirazi;Sheida Hesami;Alireza Nourian;Abdolkarim Hosseini
作者机构：
Department of Biology,Faculty of Basic Sciences,Bu-Ali Sina University,Hamedan 6517433391,Iran;Department of Pathobiology,Faculty of Veterinary Science,Bu-Ali Sina University,Hamedan 6517433391,Iran;Department of Animal Sciences and Biotechnology,Faculty of Life Sciences and Biotechnology,Shahid Beheshti University,Tehran 1983969411,Iran
文献出处：
引用格式：
[1]Naser Mirazi;Sheida Hesami;Alireza Nourian;Abdolkarim Hosseini-.Protective efficacy of dark chocolate in letrozole-induced ovary toxicity model rats:hormonal,biochemical,and histopathological investigation)[J].中医杂志（英文版）,2022(05):741-748
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B类：
Protective,efficacy,dark,chocolate,letrozole,induced,ovary,toxicity,model,rats,hormonal,biochemical,histopathological,investigation,OBJECTIVE,To,assess,protective,DC,polycystic,syndrome,PCOS,METHODS,In,this,experimental,study,female,Wistar,weighing,were,randomly,categorized,into,groups,including,control,metformin,along,by,oral,gavage,Twenty,four,hours,after,last,supplementation,direct,blood,sampling,was,taken,from,heart,obtain,serum,evaluation,sex,hormones,gonadotropins,parameters,cytokines,ovarian,tissue,examined,histology,RESULTS,treatment,significantly,improved,signs,demonstrated,restoration,morphology,physiological,functions,compared,also,decreased,interleukin,tumor,necrosis,levels,total,antioxidative,status,CONCLUSIONS,Treating,animals,could,alleviate,symptoms,reduced,effects,This,may,mediate,through,antioxidant,antiinflammatory,properties
AB值：
0.628629
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