典型文献
Glinus lotoides ethanolic extract alleviates LPS-induced anxiety and depression-like behavior by modulating antioxidant and inflammatory biomarkers in rats
文献摘要：
Objective: To explore the protective role of Glinus lotoides ethanolic extract in a depression model through modulating oxidant/antioxidant enzyme system and inflammatory status. Methods: Phytochemical constituents of Glinus lotoides ethanolic extract were evaluated qualitatively and quantitatively along with HPLC. Rats were divided into six groups. The normal control and the intoxicated groups received normal saline, and the standard group received imipramine, while the remaining groups received 100, 300, and 500 mg/kg Glinus lotoides ethanolic extract. All groups received treatments for 14 d. Lipopolysaccharides (LPS) were then administered i.p. (0.83 mg/kg) to all groups except the normal control group. After 24 h, anxiety and depression-like behaviors were evaluated by performing behavioral analysis (open field, tail suspension, forced swim, sucrose preference test), and determining total oxidant status, total antioxidant capacity, catalase, and biochemical parameters [malondialdehyde, glutathione, superoxide dismutase, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6]. Results: Phytochemical studies confirmed the presence of phenols and flavonoids and HPLC analysis showed the presence of gallic acid, quercetin, chlorogenic, and caffeic acid. Total oxidant status was significantly decreased, while total antioxidant capacity was significantly increased in the Glinus lotoides ethanolic extract treated groups. Moreover, Glinus lotoides ethanolic extract diminished malondialdehyde, IL-6, and TNF-alpha levels, while increasing superoxide dismutase, catalase, and glutathione activities. Conclusions: Glinus lotoides ethanolic crude extract shows significant antidepressant activity by modulating oxidative and biochemical parameters that supports its folkloric use in traditional systems of medicine.
文献关键词：
中图分类号：
作者姓名：
Ambreen Mehmood Awan;Wafa Majeed;Faraza Javed;Bilal Aslam;Asra Iftikhar;Hafiza Arooj Kanwal;Sobia Fiaz
作者机构：
Institute of Physiology and Pharmacology,University of Agriculture,Faisalabad,Pakistan;Department of Pharmacy,University of Agriculture,Faisalabad,Pakistan;Department of Pharmacology,Faculty of Pharmacy,the Islamia University of Bahawalpur,Bahawalpur,Pakistan;Department of Pharmacy,University of Faisalabad,Faisalabad,Pakistan
文献出处：
引用格式：
[1]Ambreen Mehmood Awan;Wafa Majeed;Faraza Javed;Bilal Aslam;Asra Iftikhar;Hafiza Arooj Kanwal;Sobia Fiaz-.Glinus lotoides ethanolic extract alleviates LPS-induced anxiety and depression-like behavior by modulating antioxidant and inflammatory biomarkers in rats)[J].亚太热带生物医学杂志（英文版）,2022(02):78-86
A类：
Glinus,lotoides,imipramine,folkloric
B类：
ethanolic,extract,alleviates,LPS,induced,anxiety,depression,like,by,modulating,antioxidant,inflammatory,biomarkers,rats,Objective,explore,protective,role,model,through,enzyme,status,Methods,Phytochemical,constituents,were,evaluated,qualitatively,quantitatively,along,HPLC,Rats,divided,six,groups,normal,control,intoxicated,received,saline,standard,while,remaining,All,treatments,Lipopolysaccharides,then,administered,except,After,behaviors,performing,behavioral,analysis,open,field,tail,suspension,forced,swim,sucrose,preference,test,determining,total,capacity,catalase,biochemical,parameters,malondialdehyde,glutathione,superoxide,dismutase,tumor,necrosis,alpha,interleukin,Results,studies,confirmed,presence,phenols,flavonoids,showed,gallic,acid,quercetin,chlorogenic,caffeic,Total,was,significantly,decreased,increased,treated,Moreover,diminished,levels,increasing,activities,Conclusions,crude,shows,antidepressant,activity,oxidative,that,supports,its,use,traditional,systems,medicine
AB值：
0.477898
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