典型文献
Anti-angiogenesis and anti-inflammatory effects of Moringa oleifera leaf extract in the early stages of streptozotocin-induced diabetic nephropathy in rats
文献摘要：
Objective: To investigate the effect of Moringa oleifera leaf extract on angiogenesis and inflammatory process in a rat model of streptozotocin-induced diabetic nephropathy. Methods: Four weeks after a single injection of 50 mg/kg streptozotocin, rats were treated with 100 or 200 mg/kg/day Moringa oleifera leaf extract, 1 mg/kg/day dapagliflozin, or a combination of Moringa oleifera leaf extract and dapagliflozin for further eight weeks. Renal function, kidney histology, and gene expression were evaluated at the end of the experiment. Results: Renal function of diabetic rats was significantly impaired as evidenced by increased blood urea nitrogen, albuminuria, 24-h proteinuria, and high creatinine clearance which indicated glomerular hyperfiltration. In addition, diabetic rats showed an increase in gene expressions of vascular endothelial growth factor-A (VEGF-A), angiopoietin-2 (Ang2), the Ang2/Ang1 ratio, tumor necrosis factor-α, interleukin-1β and monocyte chemoattractant protein-1. Immunohistochemical staining demonstrated a significant increase in the density of glycoprotein CD34. Moringa oleifera leaf extract markedly improved all renal dysfunction markers and modulated the upregulated expression of angiogenic factors and inflammatory genes. Conclusions: Moringa oleifera leaf extract could suppress abnormal angiogenesis and inflammatory processes possibly by downregulating gene expression of angiogenesis factors and proinflammatory cytokines.
文献关键词：
中图分类号：
作者姓名：
Ruttiya Thongrung;Laddawan Senggunprai;Wiphawi Hipkaeo;Panot Tangsucharit;Patchareewan Pannangpetch
作者机构：
Department of Pharmacology,Faculty of Medicine,Khon Kaen University,Khon Kaen,40002,Thailand;Cardiovascular Research Group,Khon Kaen University,Khon Kaen,40002,Thailand;Department of Anatomy,Electron Microscopy Unit,Faculty of Medicine,Khon Kaen University,Khon Kaen,40002,Thailand
文献出处：
引用格式：
[1]Ruttiya Thongrung;Laddawan Senggunprai;Wiphawi Hipkaeo;Panot Tangsucharit;Patchareewan Pannangpetch-.Anti-angiogenesis and anti-inflammatory effects of Moringa oleifera leaf extract in the early stages of streptozotocin-induced diabetic nephropathy in rats)[J].亚太热带生物医学杂志（英文版）,2022(07):290-299
A类：
dapagliflozin,hyperfiltration
B类：
Anti,angiogenesis,anti,effects,Moringa,oleifera,leaf,extract,early,stages,streptozotocin,induced,diabetic,nephropathy,rats,Objective,To,investigate,model,Methods,Four,weeks,after,single,injection,were,treated,day,combination,further,eight,Renal,kidney,histology,evaluated,experiment,Results,was,significantly,impaired,evidenced,by,increased,blood,urea,nitrogen,albuminuria,proteinuria,high,creatinine,clearance,which,indicated,glomerular,In,addition,showed,expressions,vascular,endothelial,growth,VEGF,angiopoietin,Ang2,Ang1,tumor,necrosis,interleukin,monocyte,chemoattractant,Immunohistochemical,staining,demonstrated,density,glycoprotein,CD34,markedly,improved,all,renal,dysfunction,markers,modulated,upregulated,angiogenic,factors,Conclusions,could,suppress,abnormal,processes,possibly,downregulating,proinflammatory,cytokines
AB值：
0.511735
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
