典型文献
Persea americana attenuates inflammatory response associated with hyperlipidemia in ovariectomized and irradiated rats by regulating MMP-3/TIMP-1 levels
文献摘要：
Objective: To explore the effect of Persea americana supplementation on inlfammation, oxidative stress, and lipid proifles in ovariectomized rats fed with a high-fat diet and exposed to radiation. Methods: The control group was sham operated, while groups 2-5 were ovariectomized and fed a high-fat diet. Groups 4 and 5 were exposed to γ-radiation (1 Gy/week for 5 weeks) after ovariectomy. Groups 3 and 5 were treated with 1 mL/250 g/day of Persea americana for one month. Serum levels of estrogen, alanine aminotransferase, aspartate aminotransferase, cholesterol, triglycerides and lipoproteins were measured. Additionally, hepatic oxidative stress, inflammatory and fibrogenic markers were evaluated. Results: Persea americana treatment reduced the oxidative stress markers as well as the levels of triglyceride, total cholesterol, and low-density lipoprotein cholesterol, which in turn lowered hepatic fat accumulation. Moreover, it suppressed hepatic inlfammatory mediators (interleukin-6, tumor necrosis factor-α, and C-reactive protein) and downregulated pro-ifbrogenic markers (transforming growth factor-βand tissue inhibitor of metalloproteinase-1). Conclusions: Persea americana provides protection against ovariectomy, and gamma radiation-mediated hepatic inflammation not only through its antioxidant, anti-inflammatory, lipid-lowering effect but also by modulating the ifbrogenic markers.
文献关键词：
中图分类号：
作者姓名：
Dina F.Elmaghraby;Fatma A.M.Salem;Esraa S.A.Ahmed
作者机构：
Department of Health Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt;Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt;Radiation Biology Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt
文献出处：
引用格式：
[1]Dina F.Elmaghraby;Fatma A.M.Salem;Esraa S.A.Ahmed-.Persea americana attenuates inflammatory response associated with hyperlipidemia in ovariectomized and irradiated rats by regulating MMP-3/TIMP-1 levels)[J].亚太热带生物医学杂志（英文版）,2022(09):374-382
A类：
Persea,inlfammation,proifles,inlfammatory,ifbrogenic
B类：
americana,attenuates,inflammatory,response,associated,hyperlipidemia,ovariectomized,irradiated,rats,by,regulating,MMP,TIMP,levels,Objective,To,explore,effect,supplementation,oxidative,stress,fed,high,fat,diet,exposed,radiation,Methods,control,was,sham,operated,while,groups,Groups,Gy,weeks,after,ovariectomy,treated,day,one,month,Serum,estrogen,alanine,aminotransferase,aspartate,cholesterol,triglycerides,lipoproteins,measured,Additionally,hepatic,fibrogenic,markers,evaluated,Results,treatment,reduced,well,total,density,which,turn,lowered,accumulation,Moreover,suppressed,mediators,interleukin,tumor,necrosis,reactive,downregulated,transforming,growth,tissue,inhibitor,metalloproteinase,Conclusions,provides,protection,against,gamma,mediated,inflammation,only,through,its,antioxidant,lowering,but,also,modulating
AB值：
0.509373
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