典型文献
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 expression and its relationship with T cell activation in human immunodeficiency virus/acquired immune deficiency syndrome patients with lung-spleen Qi deficiency syndrome pattern
文献摘要：
OBJECTIVE:To investigate the relationship between antiviral restriction factor Sterile Alpha Motif and Histidine-Aspartic acid domain-containing protein 1(SAMHD1)expression and T cell activation,furthermore,identifying objective indexes of lung-spleen Qi deficiency symptom pattern.METHODS:We assessed the profile of T lymphocyte subsets,characteristics of SAMHD1 and human leukocyte antigen DR(HLA-DR)expression in lung-spleen Qi deficiency patients.At the same time,people living with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)(PLWHA)without obvious clinical symptoms and healthy donors in this area were used as controls.RESULTS:Immunohematologic indexes lower CD4 count,lower CD4/CD8 ratio and higher SAMHD1 level were found in lung-spleen Qi deficiency patients.Furthermore,we demonstrated a positive relationship between SAMHD1 and HLA-DR level as well as with interferon factor in lung-spleen Qi deficiency syndrome and patients without obvious clinical signs and symptoms groups.CONCLUSIONS:These data indicated the positive relationship between SAMHD1 and T cell activation which further elucidated the role of SAMHD1 in cellular immune response.Furthermore,combination of T lymphocyte subsets counts and SAMHD1 level may be used as clinical and biological reference basis for the differentiation and diagnosis of HIV/AIDS traditional Chinese medicine syndromes.
文献关键词：
中图分类号：
作者姓名：
LIU Zhen;ZHANG Qingyan;DENG Bowen;SANG Feng;WANG Danni;KANG Ning;LI Jie;ZHANG Min;LIANG Shoupei;DUAN Chenchen;LIU Zhibin;XU Qianlei;LI Qiang
作者机构：
Henan Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Department of Acquired Immune Deficiency Syndrome Treatment and Research Center,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Department of Obstetrics and Gynecology,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Medical Department,Medical Department of Zhengzhou People's Hospital,Zhengzhou 450000,China
文献出处：
引用格式：
[1]LIU Zhen;ZHANG Qingyan;DENG Bowen;SANG Feng;WANG Danni;KANG Ning;LI Jie;ZHANG Min;LIANG Shoupei;DUAN Chenchen;LIU Zhibin;XU Qianlei;LI Qiang-.Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 expression and its relationship with T cell activation in human immunodeficiency virus/acquired immune deficiency syndrome patients with lung-spleen Qi deficiency syndrome pattern)[J].中医杂志（英文版）,2022(03):451-457
A类：
Immunohematologic
B类：
Sterile,alpha,motif,histidine,aspartic,acid,domain,containing,protein,expression,its,relationship,activation,human,immunodeficiency,virus,acquired,immune,patients,lung,spleen,Qi,pattern,OBJECTIVE,To,investigate,between,antiviral,restriction,Alpha,Motif,Histidine,Aspartic,SAMHD1,furthermore,identifying,objective,indexes,METHODS,We,assessed,profile,lymphocyte,subsets,characteristics,leukocyte,antigen,DR,HLA,At,same,people,living,HIV,AIDS,PLWHA,without,obvious,clinical,symptoms,healthy,donors,this,area,were,used,controls,RESULTS,lower,CD4,CD8,ratio,higher,level,found,Furthermore,demonstrated,positive,well,interferon,signs,groups,CONCLUSIONS,These,data,indicated,which,elucidated,role,cellular,response,combination,counts,may,biological,reference,basis,differentiation,diagnosis,traditional,Chinese,medicine,syndromes
AB值：
0.500515
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