Jing CHEN;Jian CHEN;Lie WANG-Department of Gastrointestinal Surgery,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;Institute of Immunology and Bone Marrow Transplantation Center,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou 311121,China;Cancer Center,Zhejiang University,Hangzhou 310058,China

Mingyan He;Jing Hu;Tingting Fang;Wenqing Tang;Bei Lv;Biwei Yang;Jinglin Xia-Department of Gastroenterology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Liver Cancer Institute,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Cardiology,Jiangxi Provincial People's Hospital Affiliated to Nanchang University,Nanchang 330006,China;Department of Oncology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China

Siyi Zheng;Hui Han;Shuibin Lin-Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China

Yu Deng;Hongyan Jin-Department of Obstetrics and Gynecology,Peking University First Hospital,Beijing 100034,China

Vladimir Semiglazov;Andrey Tseluiko;Asel Kudaybergenova;Anna Artemyeva;Petr Krivorotko;Roman Donskih-Petrov National Medicine Cancer-Research Center Ministry of Health,Saint-Petersburg 197758,Russia

Hai Hu;Ni Yao;Xiao-qin Lai-Emergency Management Office of West China Hospital,Sichuan University,Chengdu 610041,China;China International Emergency Medical Team,Chengdu 610041,China;Sichuan University's Emergency Medical Rescue Base,Chengdu 610041,China;Department of Critical Care Medicine,West China Hospital,Sichuan University,Chengdu 610041,China;Day Surgery Center,West China Hospital,Sichuan University,Chengdu 610041,China;West China School of Nursing,Sichuan University,Chengdu 610041,China

Zi-Wen Tao;Bao-Quan Cheng Tao Zhou;Yan-Jing Gao-Department of Gastroenterology,Qilu Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250012,China

Hong-Kun Di;Yong Gan;Kai Lu;Chao Wang;Yi Zhu;Xin Meng;Wen-Qi Xia;Min-Zhi Xu;Jing Feng;Qing-Feng Tian;Yan He;Zhi-Qiang Nie;Jun-An Liu;Fu-Jian Song;Zu-Xun Lu-Department of Social Medicine and Health Management,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,No.13 Hangkong Road,Wuhan 430030,Hubei,China;Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China;School of Public Health,Zhengzhou University,Zhengzhou,Henan,China;Norwich Medical School,Faculty of Medicine and Health Science,University of East Anglia,Norwich NR47TJ,UK

Shujia Chen;Siang Wei;Jiwei Wang-Department of Gastroenterology,Panjin Central Hospital Affiliated to Jinzhou Medical University,Panjin 124000,China;Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Gastrointestinal Surgery,Xuzhou Central Hospital,Xuzhou 221009,China

Jun-peng Yao;Li-ping Chen;Xian-jun Xiao;Ting-hui Hou;Si-yuan Zhou;Ming-min Xu;Kai Wang;Yu-jun Hou;Lin Zhang;Ying Li-Acupuncture and Tuina School,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;School of Health Preservation and Rehabilitation,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Department of General Practice,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China;Graduate School,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China

Gil Diego;Tiscar Carlos;Gómez Maria;Felices Javier;Gajate Luis;Fernandez Patricia;Pesta?a David;Bardi Tommaso-Department of Anaesthesiology and Critical Care, Ramón y Cajal Hospital, 28034 Madrid, Spain;Department of Psychology, Ramón y Cajal Hospital, 28034 Madrid, Spain

Kassim Kourbanhoussen;France-Hélène Joncas;Christopher JD Wallis;Hélène Hovington;Fran?ois Dagenais;Yves Fradet;Chantal Guillemette;Louis Lacombe;Paul Toren-Department of Surgery,Faculty of Medicine,Université Laval,CHU de Québec Research Center,Oncology Division,Quebec City G1R3S1,Canada;Department of Urology,Vanderbilt University Medical Center,Nashville,TN 37232,USA;lnstitut Universitaire Cardiologie et Pneumologie de Québec,Quebec City G1V 4G5,Canada;Faculty of Pharmacy,Université Laval,CHU de Québec Research Center,Quebec City G1V 4G2,Canada

Assane Hamidou Abdoulaye;Jichun Jia;Aqleem Abbas;Du Hai;Jiasen Cheng;Yanping Fu;Yang Lin;Daohong Jiang;Jiatao Xie-State Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan,430070,China;Hubei Key Laboratory of Plant Pathology,College of Plant Science and Technology,Huazhong Agricultural University,Wuhan,430070,China;Hubei Hongshan Laboratory,Wuhan,430070,China

Zhao Huang;Jingyuan Wen;Yufei Wang;Shenqi Han;Zhen Li;Xuemei Hu;Dongling Zhu;Zhenxiong Wang;Junnan Liang;Huifang Liang;Xiao-ping Chen;Bixiang Zhang-Hepatic Surgery Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Clinical Medical Research Center of Hepatic Surgery at Hubei Province,Wuhan 430030,China;Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Radiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Nuclear Medicine and PET Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Radiology,Guangzhou First People's Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China;Key Laboratory of Organ Transplantation,Ministry of Education;Key Laboratory of Organ Transplantation,National Health Commission;Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Wuhan 430030,China

Chao Deng;Lin Zhao;Zhi Yang;Jia-jia Shang;Chang-yu Wang;Ming-zhi Shen;Shuai Jiang;Tian Li;Wen-cheng Di;Ying Chen;He Li;Ye-dong Cheng;Yang Yang-Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases,Xi'an No.3 Hospital,School of Life Sciences and Medicine,Northwest University,Xi'an 710021,China;Department of Orthopaedics,Huaian Medical District of Jingling Hospital,Medical School of Nanjing University,Huaian 213001,China;Department of Cardiovascular Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Department of Cardiovascular Surgery,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032,China;Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education.Life of Sciences,Northwest University,Xi'an 710021,China;Department of Cardiology,Xi'an No.3 Hospital,School of Life Sciences and Medicine,Northwest University,Xi'an 710021,China;Hainan Hospital of PLA General Hospital,The Second School of Clinical Medicine,Southern Medical University,Sanya 572013,China;National Clinical Research Center for Infectious Diseases,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen 518100,China;Department of Hematology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China

Xiao Guan;Guo-rong Dan;Yao Yang;Yan Ji;Wen-jing Lai;Fang-jie Wang;Meng Meng;Bang-hui Mo;Pei Huang;Ting-ting You;Ya-fei Deng;Liang Song;Wei Guo;Ping Yi;Jian-hua Yu;Yuan Gao;Wei-nian Shou;Bing-bo Chen;You-cai Deng;Xiao-hui Li-Institute of Materia Medica,College of Pharmacy,Army Medical University(Third Military Medical University),Chongqing 400038,China;Department of Obstetrics and Gynecology,The Third Affiliated Hospital of Chongqing Medical University,Chongqing 401120,China;The Ohio State University Comprehensive Cancer Center and the James Cancer Hospital,Columbus,OH 43210,USA;Department of Hematology&Hematopoietic Cell Transplantation,City of Hope National Medical Center and Beckman Research Institute,Duarte,CA 91010,USA;Southwest Hospital/Southwest Eye Hospital,Army Medical University(Third Military Medical University),Chongqing 400038,China;Herman B Wells Center for Pediatric Research,Department of Pediatrics,Indiana University School of Medicine,Indianapolis,IN 46202,USA;Laboratory Animal Center,Army Medical University(Third Military Medical University),Chongqing 400038,China

Ya-jing Li;Run-ping Liu;Ming-ning Ding;Qi Zheng;Jian-zhi Wu;Xiao-yong Xue;Yi-qing Gu;Bo-ning Ma;Ya-jie Cai;Shuo Li;Sheng Lin;Lu-yong Zhang;Xiaojiaoyang Li-School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100029,China;Center for Drug Screening and Pharmacodynamics Evaluation,School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China

Qiu-ying Yan;Jian-lu Lv;Xing-yi Shen;Xing-nan Ou-Yang;Juan-zhen Yang;Rui-fang Nie;Jian Lu;Yu-jie Huang;Jia-ying Wang;Xu Shen-Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and State Key Laboratory Cultivation Base for TCM Quality and Efficacy,Nanjing University of Chinese Medicine,Nanjing 210023,China

Ning-ning Zhang;Yi Zhang;Zhen-zhen Wang;Nai-hong Chen-State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica&Neuroscience Center,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Department of Anatomy,School of Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China

He-ming Cheng;Chen-shu Gao;Qiu-wen Lou;Zhong Chen;Yi Wang-Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China;Epilepsy Center,Department of Neurology,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310058,China