典型文献
Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes
文献摘要：
Tertiary lymphoid structures (TLSs) are formations at sites with persistent inflammatory stimulation, including tumors. These ectopic lymphoid organs mainly consist of chemo-attracting B cells, T cells, and supporting dendritic cells (DCs). Mature TLSs exhibit functional organization for the optimal development and collaboration of adaptive immune response, delivering an augmented effect on the tumor microenvironment (TME). The description of the positive correlation between TLSs and tumor prognosis is reliable only under a certain condition involving the localization and maturation of TLSs. Emerging evidence suggests that underlying mechanisms of the anti-tumor effect of TLSs pave the way for novel immunotherapies. Several approaches have been developed to take advantage of intratumoral TLSs, either by combining it with therapeutic agents or by inducing the neogenesis of TLSs.
文献关键词：
中图分类号：
作者姓名：
Jing CHEN;Jian CHEN;Lie WANG
作者机构：
Department of Gastrointestinal Surgery,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;Institute of Immunology and Bone Marrow Transplantation Center,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou 311121,China;Cancer Center,Zhejiang University,Hangzhou 310058,China
引用格式：
[1]Jing CHEN;Jian CHEN;Lie WANG-.Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(10):812-822
A类：
immunocytes,TLSs,neogenesis
B类：
Tertiary,lymphoid,structures,unique,constructions,associated,organization,education,infiltrating,are,formations,sites,persistent,inflammatory,stimulation,including,tumors,These,ectopic,organs,mainly,consist,chemo,attracting,cells,supporting,dendritic,DCs,Mature,exhibit,functional,optimal,development,collaboration,adaptive,immune,response,delivering,augmented,effect,microenvironment,TME,description,positive,correlation,between,prognosis,reliable,only,certain,condition,involving,localization,maturation,Emerging,evidence,suggests,that,underlying,mechanisms,anti,pave,way,novel,immunotherapies,Several,approaches,have,been,developed,take,advantage,intratumoral,either,by,combining,therapeutic,agents,inducing
AB值：
0.628388
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
