典型文献
Applications of human amniotic fluid stem cells in wound healing
文献摘要：
Complete wound regeneration preserves skin structure and physiological functions, including sensation and perception of stimuli, whereas incomplete wound regeneration results in fibrosis and scarring. Amniotic fluid stem cells (AFSCs) would be a kind of cell population with self-renewing and non-immunogenic ability that have a considerable role in wound generation. They are easy to harvest, culture, and store; moreover, they are non-tumorigenic and not subject to ethical restrictions. They can differentiate into different kinds of cells that replenish the skin, subcutaneous tissues, and accessory organs. Additionally, AFSCs independently produce paracrine effectors and secrete them in exosomes, thereby modulating local immune cell activity. They demonstrate anti-inflammatory and immunomodulatory properties, regulate the physicochemical microenvironment of the wound, and promote full wound regeneration. Thus, AFSCs are potential resources in stem cell therapy, especially in scar-free wound healing. This review describes the biological characteristics and clinical applications of AFSCs in treating wounds and provide new ideas for the treatment of wound healing.
文献关键词：
Amniotic fluid;Stem cells;Mesenchymal stromal cells;Wound healing;Cicatrix;Hypertrophic;Tissue engineering
中图分类号：
作者姓名：
Luo Han;Wang Zhen;Qi Fang;Wang Dali
作者机构：
Department of Plastic Surgery and Burns, The Affiliated Hospital of Zunyl Medical University, Zunyl, Guizhou 563003, China;Department of Plastic Surgery and Burns, Fuling Central Hospital, Chongqing 408000, China
文献出处：
引用格式：
[1]Luo Han;Wang Zhen;Qi Fang;Wang Dali-.Applications of human amniotic fluid stem cells in wound healing)[J].中华医学杂志（英文版）,2022(19):2272-2281
A类：
Amniotic,AFSCs,renewing,Cicatrix
B类：
Applications,human,amniotic,fluid,stem,cells,healing,Complete,regeneration,preserves,skin,structure,physiological,functions,including,sensation,perception,stimuli,whereas,incomplete,results,fibrosis,scarring,would,population,self,immunogenic,ability,that,have,considerable,role,They,are,easy,harvest,culture,store,moreover,they,tumorigenic,not,subject,ethical,restrictions,can,differentiate,into,kinds,replenish,subcutaneous,tissues,accessory,organs,Additionally,independently,produce,paracrine,effectors,secrete,them,exosomes,thereby,modulating,local,immune,activity,demonstrate,anti,inflammatory,immunomodulatory,properties,regulate,physicochemical,microenvironment,promote,full,Thus,potential,resources,therapy,especially,free,This,review,describes,biological,characteristics,clinical,applications,treating,wounds,provide,ideas,treatment,Stem,Mesenchymal,stromal,Wound,Hypertrophic,Tissue,engineering
AB值：
0.626056
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