典型文献
Tumor organoids for cancer research and personalized medicine
文献摘要：
Organoids are three-dimensional culture systems generated from embryonic stem cells, induced pluripotent stem cells, and adult stem cells. They are capable of cell proliferation, differentiation, and self-renewal. Upon stimulation by signal factors and/or growth factors, organoids self-assemble to replicate the morphological and structural characteristics of the corresponding organs. They provide an extraordinary platform for investigating organ development and mimicking pathological processes. Organoid biobanks derived from a wide range of carcinomas have been established to represent different lesions or stages of clinical tumors. Importantly, genomic and transcriptomic analyses have confirmed maintenance of intra- and interpatient heterogeneities in organoids. Therefore, this technology has the potential to revolutionize drug screening and personalized medicine. In this review, we summarized the characteristics and applications of organoids in cancer research by the establishment of organoid biobanks directly from tumor organoids or from genetically modified non-cancerous organoids. We also analyzed the current state of organoid applications in drug screening and personalized medicine.
文献关键词：
中图分类号：
作者姓名：
Hui Yang;Yinuo Wang;Peng Wang;Ning Zhang;Pengyuan Wang
作者机构：
Translational Cancer Research Center,Peking University First Hospital,Beijing 100034,China;Division of General Surgery,Peking University First Hospital,Beijing 100034,China
文献出处：
引用格式：
[1]Hui Yang;Yinuo Wang;Peng Wang;Ning Zhang;Pengyuan Wang-.Tumor organoids for cancer research and personalized medicine)[J].癌症生物学与医学（英文版）,2022(03):319-332
A类：
biobanks,interpatient
B类：
Tumor,organoids,research,personalized,medicine,Organoids,are,three,dimensional,culture,systems,generated,from,embryonic,cells,induced,pluripotent,adult,They,capable,proliferation,differentiation,self,renewal,Upon,stimulation,by,signal,factors,growth,assemble,replicate,morphological,structural,characteristics,corresponding,organs,provide,extraordinary,platform,investigating,development,mimicking,pathological,processes,derived,wide,range,carcinomas,have,been,established,represent,lesions,stages,clinical,tumors,Importantly,genomic,transcriptomic,analyses,confirmed,maintenance,intra,heterogeneities,Therefore,this,technology,has,potential,revolutionize,drug,screening,In,review,we,summarized,applications,establishment,directly,genetically,modified,cancerous,We,also,analyzed,current,state
AB值：
0.592633
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
