典型文献
The shikimate pathway regulates programmed cell death
文献摘要：
Programmed cell death(PCD)is essential for both plant development and stress responses including immunity.However,how plants control PCD is not well-understood.The shikimate pathway is one of the most important metabolic pathways in plants,but its relationship to PCD is unknown.Here,we show that the shikimate pathway promotes PCD in Arabidopsis.We identify a photoperiod-dependent lesion-mimic mutant named Lesion in short-day(lis),which forms spontaneous lesions in short-day conditions.Map-based cloning and whole-genome resequencing reveal that LIS encodes MEE32,a bifunctional enzyme in the shikimate pathway.Metabolic analysis shows that the level of shikimate is dramatically increased in lis.Through genetic screenings,three suppressors of lis(slis)are identified and the causal genes are cloned.SLISes encode proteins upstream of MEE32 in the shikimate pathway.Furthermore,exogenous shikimate treatment causes PCD.Our study uncovers a link between the shikimate pathway and PCD,and suggests that the accumulation of shikimate is an alternative explanation for the action of glyphosate,the most successful herbicide.
文献关键词：
中图分类号：
作者姓名：
Xuerui Lu;Shixi Shi;Chong Wu;Xueao Zheng;Chenkun Yang;Jie Luo;Shunping Yan
作者机构：
Hubei Hongshan Laboratory,Wuhan,Hubei 430070,China;College of Life Science and Technology,Huazhong Agricultural University,Wuhan,Hubei 430070,China;National Key Laboratory of Crop Genetic Improvement,Huazhong Agricultural University,Wuhan,Hubei 430070,China
文献出处：
引用格式：
[1]Xuerui Lu;Shixi Shi;Chong Wu;Xueao Zheng;Chenkun Yang;Jie Luo;Shunping Yan-.The shikimate pathway regulates programmed cell death)[J].遗传学报,2022(10):943-951
A类：
MEE32,slis,SLISes
B类：
shikimate,regulates,programmed,cell,death,Programmed,PCD,essential,both,development,stress,responses,including,immunity,However,plants,control,not,well,understood,most,important,metabolic,pathways,but,its,relationship,unknown,Here,that,promotes,Arabidopsis,We,identify,photoperiod,dependent,mimic,mutant,named,Lesion,short,day,which,forms,spontaneous,lesions,conditions,Map,cloning,whole,genome,resequencing,reveal,encodes,bifunctional,enzyme,Metabolic,analysis,shows,level,dramatically,increased,Through,genetic,screenings,three,suppressors,are,identified,causal,genes,cloned,proteins,upstream,Furthermore,exogenous,treatment,causes,Our,study,uncovers,link,between,suggests,accumulation,alternative,explanation,action,glyphosate,successful,herbicide
AB值：
0.554824
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