典型文献
Pharmacological action of quercetin against testicular dysfunction:A mini review
文献摘要：
The testis is an immune-privileged organ susceptible to oxidative stress and inflammation,two major factors implicated in male infertility.A reduction in the concentration and activities of testicular function biomarkers has been shown to correlate with impaired hypothalamic-pituitary-testicular axis and oxidative stress.However,the use of natural products to ameliorate these oxidative stress-induced changes may be essential to improving male reproductive function.Quercetin possesses several pharma-cological activities that may help to combat cellular reproduction-related assaults,such as altered sperm function and reproductive hormone dysfunction,and dysregulated testicular apoptosis,oxidative stress,and inflammation.Studies have shown that quercetin ameliorates testicular toxicity,largely by inhibiting the generation of reactive oxygen species,with the aid of the two antioxidant pharmacophores present in its ring structure.The radical-scavenging property of quercetin may alter signal transduction of oxidative stress-induced apoptosis,prevent inflammation,and increase sperm quality in relation to the hormonal concentration.In this review,the therapeutic potential of quercetin in mediating male reproductive health is discussed.
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作者姓名：
Damilare E.Rotimi;Tomilola D.Olaolu;Oluyomi S.Adeyemi
作者机构：
SDG 03 Group-Good Health&Well-being,Landmark University,Omu-Aran 251101,Kwara State,Nigeria;Department of Biochemistry,Medicinal Biochemistry,Nanomedicine&Toxicology Laboratory,Landmark University,Omu-Aran 251101,Kwara State,Nigeria
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引用格式：
[1]Damilare E.Rotimi;Tomilola D.Olaolu;Oluyomi S.Adeyemi-.Pharmacological action of quercetin against testicular dysfunction:A mini review)[J].结合医学学报（英文版）,2022(05):396-401
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