典型文献
Hydroxyl radical-involved cancer therapy via Fenton reactions
文献摘要：
The tumor microenvironment features over-expressed hydrogen peroxide (H2O2).Thus,versatile therapeutic strategies based on H2O2 as a reaction substrate to generate hydroxyl radical (·OH) have been used as a prospective therapeutic method to boost anticancer efficiency.However,the limited Fenton catalysts and insufficient endogenous H2O2 content in tumor sites greatly hinder ·OH production,failing to achieve the desired therapeutic effect.Therefore,supplying Fenton catalysts and elevating H2O2 levels into cancer cells are effective strategies to improve ·OH generation.These therapeutic strategies are systematically discussed in this review.Furthermore,the challenges and future develop-ments of hydroxyl radical-involved cancer therapy are discussed to improve therapeutic efficacy.
文献关键词：
中图分类号：
作者姓名：
Mengying Liu;Yun Xu;Yanjun Zhao;Zheng Wang;Dunyun Shi
作者机构：
School of Pharmaceutical Science & Technology,Tianjin University,Tianjin 300072,China;Central Lab,Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University,Shenzhen 518035,China;Institute of Hematology,Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University,Shenzhen 518035,China
文献出处：
引用格式：
[1]Mengying Liu;Yun Xu;Yanjun Zhao;Zheng Wang;Dunyun Shi-.Hydroxyl radical-involved cancer therapy via Fenton reactions)[J].化学科学与工程前沿,2022(03):345-363
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AB值：
0.639259
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