典型文献
Effect of Antibacterial Enoxacin on the Properties of Injectable Nano-hydroxyapatite/Polyurethane Cement for Bone Repairing
文献摘要：
Biomaterial-associated infection(BAI)is a kind of serious post-operative complication in orthopaedic surgery.Antibiotic-loaded bone cement shines a light on BAI prevention for convenient manipulation and complex filling.To this aim,we designed an antibacterial bone cement based on Nano-hydroxyapatite/Polyurethane(PUHA)loading with antibiotic Enoxacin(EN).The distinct shear-thinning behavior of the prepolymers was observed,indicating a good injectability.The PUHA bone cement possessed a suitable curing speed,and the addition of EN might slightly expedite the curing process and enhance the mechanical properties.The EN release profile indicated that the EN-loaded bone cement could reach the minimum inhibitory concentration in 2 h,and sustainedly released EN for almost 8 days,exhibiting an antibacterial delivery potential.Antibac-terial test further confirmed the antibacterial ability of EN-loaded bone cement is in a dose-dependent manner.However,the osteogenic performance of drug-loaded bone cement with high dosage is not as good as antibacterial activity.When the EN concentration of antibacterial cement was lower than 32 μg·mL-1,the proliferation and osteogenic differentiation of rat mesenchymal stem cells could be significantly promoted.Overall,this study verified the potential of the EN-loaded PUHA bone cement in anti-infection and osteogenesis for bone repairing.
文献关键词：
中图分类号：
作者姓名：
Jinzheng Zhang;Xiaoyu Lei;Jiajing Tang;Jie Chen;Qing Zhao;Wei Fang;Yinglong Zhang;Yubao Li;Yi Zuo
作者机构：
Research Center for Nano-Biomaterials,Analytical and Testing Center,Sichuan University,Chengdu 610064,People's Republic of China
文献出处：
引用格式：
[1]Jinzheng Zhang;Xiaoyu Lei;Jiajing Tang;Jie Chen;Qing Zhao;Wei Fang;Yinglong Zhang;Yubao Li;Yi Zuo-.Effect of Antibacterial Enoxacin on the Properties of Injectable Nano-hydroxyapatite/Polyurethane Cement for Bone Repairing)[J].仿生工程学报（英文版）,2022(02):483-496
A类：
Enoxacin,PUHA,sustainedly,Antibac
B类：
Effect,Antibacterial,Properties,Injectable,Nano,hydroxyapatite,Polyurethane,Cement,Bone,Repairing,Biomaterial,associated,infection,BAI,kind,serious,post,operative,complication,orthopaedic,surgery,Antibiotic,loaded,bone,cement,shines,prevention,convenient,manipulation,complex,filling,To,this,aim,designed,antibacterial,loading,antibiotic,EN,distinct,shear,thinning,behavior,prepolymers,was,observed,indicating,good,injectability,possessed,suitable,curing,speed,addition,might,slightly,expedite,process,enhance,mechanical,properties,profile,indicated,that,could,reach,minimum,inhibitory,concentration,released,almost,days,exhibiting,delivery,potential,test,further,confirmed,dose,dependent,manner,However,osteogenic,performance,drug,high,dosage,not,activity,When,lower,proliferation,differentiation,mesenchymal,stem,cells,significantly,promoted,Overall,study,verified,osteogenesis,repairing
AB值：
0.536201
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
