Accumulating evidence implicates that offspring are susceptible to paternal alterations in numerous fetal disorders,such as growth and metabolic defects.However,less study has been conducted to define the relationship between paternal zinc deficiency(ZnD)and energy metabolism of offspring.In the present study,we used a paternal ZnD exposure(Zn at 0.3 μg/g)model to test energy metabolism of male and female offspring with the intervention of diet type(high-fat diet and low-fat diet).Our results demonstrated that paternal ZnD decreased body weight(BW)gain per week(P＜0.01)and ME intake per week(P＜0.05)at 11 weeks in male offspring with high-fat diet intervention but not in female offspring.Further,anabolism and catabolism of hepatic energy products also exhibited alterations.ZnD attenuated liver glucose but increased lipids content accompanied with elevated adiponectin and reduction in leptin level in serum,which exhibited lipid metabolic disturbance and smaller ratio of liver weight to BW in male but not female offspring.The qRT-PCR and liver energy metabolites analysis revealed that paternal ZnD mainly induced reduction in glucose tolerance and lowered glucose uptaking ability in male offspring and thereby alleviated glycolysis and the tricarboxylic acid cycle(TCA)cycle,which displayed a male gender-dependency.Therefore,we propose that paternal ZnD abolishes metabolic effects in male offspring induced by diet type intervention.Our findings reveal a novel link between paternal Zn-D and offspring energy metabolism.

Guanya Li;Zhenglin Dong;Shusheng Yue;Dan Wan;Yulong Yin

Key Laboratory of Agro-Ecological Processess in Subtropical Region,Hunan Research Center of Livestock&Poultry Sciences,South-Central Experimental Station of Animal Nutrition and Feed Science in Ministry of Agriculture,Institute of Subtropical Agriculture,The Chinese Academy of Sciences,Changsha,Hunan 410125,China;Hunan International Joint Laboratory of Animal Intestinal Ecology and Health,Laboratory of Animal Nutrition and Human Health,College of Life Sciences,Hunan Normal University,Changsha,Hunan,410081,China

动物营养（英文）

[1]Guanya Li;Zhenglin Dong;Shusheng Yue;Dan Wan;Yulong Yin-.Paternal Zn-deficiency abolishes metabolic effects in offspring induced by diet type)[J].动物营养（英文）,2022(01):310-320

ZnD,anabolism

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