典型文献
Cow milk αs1-casein induces allergic responses in a mouse model of atopy
文献摘要：
αs1-Casein is a potential allergen to induce hypersensitivity in cow milk. We had identified αs1-casein and its epitopes in previous studies. The present study aimed to evaluate the allergic mechanism of αs1-casein in a BALB/c mouse model. The levels of specific IgE, mast cell proteinase, histamine and cytokines in sensitized mice were determined, and the clinical and pathological observation were evaluated. Results showed that the levels of specific IgE, mast cell proteinase, histamine, IL-4, IL-5, IL-10 increased significantly with a dose-dependent trend. The local alveolar septum collapsed or thickened, and lymphatic foci were produced in the spleen and thymus, and the inflammatory cells infiltrated in small intestinal mucosa mesenchyme. In conclusion, the levels of specific IgE, mast cell proteinase, histamine, IL-4, IL-5, IL-10 and some inflammatory factors could possibly serve as allergic biomarkers of αs1-casein, however, additional studies on signal transduction and gene expression are necessary in future.
文献关键词：
中图分类号：
作者姓名：
Guangyu Wang;Xiaofeng Yu;Yanjun Cong;Linfeng Li
作者机构：
Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients,College of Food and Health,Beijing Technology and Business University,Beijing 100048,China;Department of Dermatology,Beijing Friendship Hospital,Beijing 100050,China
文献出处：
引用格式：
[1]Guangyu Wang;Xiaofeng Yu;Yanjun Cong;Linfeng Li-.Cow milk αs1-casein induces allergic responses in a mouse model of atopy)[J].食品科学与人类健康（英文）,2022(05):1282-1289
A类：
atopy,mesenchyme
B类：
Cow,milk,s1,casein,induces,allergic,responses,mouse,model,Casein,potential,allergen,hypersensitivity,cow,We,had,identified,its,epitopes,previous,studies,present,study,aimed,mechanism,BALB,levels,specific,IgE,mast,proteinase,histamine,cytokines,sensitized,mice,were,determined,clinical,pathological,observation,evaluated,Results,showed,that,increased,significantly,dose,dependent,trend,local,alveolar,septum,collapsed,thickened,lymphatic,foci,produced,spleen,thymus,inflammatory,cells,infiltrated,small,intestinal,mucosa,In,conclusion,some,factors,could,possibly,serve,biomarkers,however,additional,signal,transduction,gene,expression,are,necessary,future
AB值：
0.587719
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