典型文献
Chicory polysaccharides alleviate high-fat diet-induced non-alcoholic fatty liver disease via alteration of lipid metabolism- and inflammation-related gene expression
文献摘要：
Administration of chicory polysaccharides (CP) can modify lipid metabolism, improve dyslipidemia, and reduce liver inflammation, all of which may help alleviate non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms remain unclear. This study aimed to gain further understanding of the potential molecular mechanisms that mediate the protective effects of CP against NAFLD via transcriptomic and metabolomic analyses. Hepatic RNA-sequencing analysis demonstrated that long-term intake of CP restored expression of lipid metabolism-related genes Xbp1, Insig2, and Cth in NAFLD rats, thereby inhibiting de novo lipogenesis. Moreover, CP consumption restored expression levels of genes involved in pro-inflammatory responses, such as Irf1. In addition, metabolic data confirmed that CP treatment increased levels of L-palmitoylcarnitine and hexadecanoyl-CoA, implying that CP administration can promote hepatic fatty acid β-oxidation. The present results demonstrate the underlying mechanisms of CP in high-fat diet-induced NAFLD rats and suggest that CP treatment might provide a dietary therapeutic tool for the treatment of NAFLD in humans.
文献关键词：
中图分类号：
作者姓名：
Shengjie Li;Yulong Wu;Haitao Jiang;Feng Zhou;Ailing Ben;Renlei Wang;Chun Hua
作者机构：
School of Food Science,Nanjing Xiaozhuang University,Nanjing 211171,China;Jiangsu Provincial Key Construction Laboratory of Special Biomass Byproduct Resource Utilization,Nanjing 211171,China;Nanjing Key Laboratory of Quality and safety of agricultural products,Nanjing 211171,China;Biology Department,Jiangsu Second Normal University,Nanjing 210013,China
文献出处：
引用格式：
[1]Shengjie Li;Yulong Wu;Haitao Jiang;Feng Zhou;Ailing Ben;Renlei Wang;Chun Hua-.Chicory polysaccharides alleviate high-fat diet-induced non-alcoholic fatty liver disease via alteration of lipid metabolism- and inflammation-related gene expression)[J].食品科学与人类健康（英文）,2022(04):954-964
A类：
Chicory,Xbp1,Insig2,Cth,Irf1,palmitoylcarnitine,hexadecanoyl
B类：
polysaccharides,alleviate,high,induced,alcoholic,fatty,liver,disease,alteration,metabolism,inflammation,related,expression,Administration,chicory,CP,modify,improve,dyslipidemia,reduce,which,may,help,NAFLD,However,underlying,mechanisms,remain,unclear,This,study,aimed,further,understanding,potential,molecular,that,mediate,protective,effects,against,transcriptomic,metabolomic,analyses,Hepatic,sequencing,analysis,demonstrated,long,term,intake,restored,rats,thereby,inhibiting,novo,lipogenesis,Moreover,consumption,levels,involved,inflammatory,responses,such,addition,metabolic,data,confirmed,treatment,increased,CoA,implying,administration,promote,hepatic,acid,oxidation,present,results,suggest,might,provide,dietary,therapeutic,tool,humans
AB值：
0.513974
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