Long-term artificial sweetener intake is linked to increased risk of obesity. In the present study, supplement of natural sweetener from Siraitia grosvenorii (SG) (or Momordica grosvenorii) fruit, compared with the artificial sweetener aspartame (ASM), was evaluated for anti-obesity effects on mice fed with high fat diet (HFD). We found that, in contrary to ASM, SG extracts prevented body weight gain, the insulin resistance and fat mass accumulation in HFD mice. SG extracts treatment inhibited the infiltration of inflammatory macrophages and lowered the levels of the fat inflammatory cytokines (leptin, macrophage chemoattractant protein 1 (MCP-1) and tumor necrosis factor-α (TNF-α)) in adipose tissues. In addition, SG extracts supplement counteracted the remodeling of gut microbiota resulted from HFD. However, ASM supplement aggravated the HFD-induced obese performances, fat inflammation and dysregulation of gut microbiota. Taken together, our results indicate that supplement of SG extracts may represent a promising alternation of artificial sweeteners in preventing metabolic diseases.

Tianjin Key Laboratory of Food and Biotechnology,School of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China;Department of Biochemical Engineering,School of Chemical Engineering and Technology,Key Laboratory of Systems Bioengineering,Ministry of Education,Tianjin University,Tianjin 300072,China;Department of Food Science,Rutgers,The State University of New Jersey,New Brunswick,NJ 08901,USA;Department of Plant Biology,Rutgers,The State University of New Jersey,New Brunswick,NJ 08901,USA

[1]Ke Lü;Xiaowan Song;Peng Zhang;Wei Zhao;Ning Zhang;Fan Yang;Wenqiang Guan;Jianfu Liu;He Huang;Chi-Tang Ho;Rong Di;Hui Zhao-.Effects of Siraitia grosvenorii extracts on high fat diet-induced obese mice: a comparison with artificial sweetener aspartame)[J].食品科学与人类健康（英文）,2022(04):865-873

Siraitia,aspartame,sweeteners

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