典型文献
Comparative proteomic analysis reveals the effects of different fatty acid forms on high-fat diet mice
文献摘要：
Long-chain omega-3 polyunsaturated fatty acids(LC-PUFAs),known for having many health benefits,are usually present in three forms:triglycerides(TG),ethyl esters(EE),and phospholipid(PL).In this study,the effects of these three LC-PUFAs forms(fish oil for TG and EE,krill oil for PL)on the obese mice were compared,and the proteomic changes that focused on lipid metabolism were evaluated via label-free quantitative proteomics analysis.Compared with the model group,all three of the LC-PUFA form supplementations(labeled as the FO-TG group,FO-EE group and KO-PL groups)could significantly reduce body weight gain(P＜0.01).Low-density lipoprotein cholesterol levels were significantly decreased,whereas high-density lipoprotein cholesterol levels were significantly increased in the FO-TG group and FO-EE group(P＜0.01),and especially in the PL group(P＜0.001).Furthermore,proteomics analysis results suggested that some differentially expressed genes involved in the fatty acid degradation and oxidation pathways had a higher expression fold in the KO-PL group than in the FO-TG or FO-EE groups.Our results showed that dietary LC-PUFAs can reduce fat deposition and inhibit lipogenesis in the liver by upregulating the expression of proteins that are involved in the fatty acid degradation and oxidation pathways.Additionally,KO-PL elicits stronger effects than FO-TG or FO-EE.
文献关键词：
中图分类号：
作者姓名：
Jiaping Pan;Huan Wang;Ye Li;Chenyang Lu
作者机构：
School of Marine Science,Ningbo University,Ningbo 315832,China;Collage of Food and Pharmaceutical Sciences,Ningbo University,Ningbo 315832,China
文献出处：
引用格式：
[1]Jiaping Pan;Huan Wang;Ye Li;Chenyang Lu-.Comparative proteomic analysis reveals the effects of different fatty acid forms on high-fat diet mice)[J].食品科学与人类健康（英文）,2022(02):316-322
A类：
supplementations
B类：
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AB值：
0.47032
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