典型文献
Determining the protective effects of Ma-Mu-Ran Antidiarrheal Capsules against acute DSS-induced enteritis using 16S rRNA gene sequencing and fecal metabolomics
文献摘要：
Ma-Mu-Ran Antidiarrheal Capsules(MMRAC)is traditional Chinese medicine that has been used to treat diarrhea caused by acute enteritis(AE)and bacillary dysentery in Xinjiang(China)for many years.However,the potential therapeutic mechan-ism of MMRAC for AE and its regulatory mechanism on host metabolism is unclear.This study used fecal metabolomics profiling with GC/MS and 16S rRNA gene sequencing analysis to explore the potential regulatory mechanisms of MMRAC on a dextran sulfate sodium salt(DSS)-induced mouse model of AE.Fecal metabolomics-based analyses were performed to detect the differentially ex-pressed metabolites and metabolic pathways.The 16S rRNA gene sequencing analysis was used to assess the altered gut microbes at the genus level and for functional prediction.Moreover,Pearson correlation analysis was used to integrate differentially expressed metabolites and altered bacterial genera.The results revealed that six intestinal bacteria and seven metabolites mediated metabolic dis-orders(i.e.,metabolism of amino acid,carbohydrate,cofactors and vitamins,and lipid)in AE mice.Besides,ten altered microbes me-diated the differential expression of eight metabolites and regulated these metabolisms after MMRAC administration.Overall,these findings demonstrate that AE is associated with metabolic disorders and microbial dysbiosis.Further,we present that MMRAC exerts protective effects against AE by improving host metabolism through the intestinal flora.
文献关键词：
中图分类号：
作者姓名：
ZHENG Si-Li;ZHANG Dong-Ning;DUAN Yan-Fen;HUANG Fang;HAN Lin-Tao;MO Guo-Yan
作者机构：
Pharmacy Faculty,Hubei University of Chinese Medicine,Wuhan 430065,China;Xinjiang Uygur Pharmaceutical Co.,Ltd.,Urumqi,Xinjiang 830026,China;College of Basic Medical Sciences,Hubei University of Chinese Medicine,Wuhan 430065,China
文献出处：
引用格式：
[1]ZHENG Si-Li;ZHANG Dong-Ning;DUAN Yan-Fen;HUANG Fang;HAN Lin-Tao;MO Guo-Yan-.Determining the protective effects of Ma-Mu-Ran Antidiarrheal Capsules against acute DSS-induced enteritis using 16S rRNA gene sequencing and fecal metabolomics)[J].中国天然药物,2022(05):364-377
A类：
Antidiarrheal,MMRAC,bacillary,dysentery
B类：
Determining,protective,effects,Ma,Mu,Ran,Capsules,against,acute,DSS,induced,enteritis,using,16S,rRNA,sequencing,fecal,metabolomics,traditional,Chinese,medicine,that,has,been,treat,caused,by,AE,Xinjiang,China,many,years,However,potential,therapeutic,its,regulatory,host,unclear,This,study,profiling,analysis,explore,mechanisms,dextran,sulfate,sodium,salt,mouse,model,Fecal,analyses,were,performed,detect,differentially,metabolites,metabolic,pathways,was,assess,altered,gut,microbes,genus,level,functional,prediction,Moreover,correlation,integrate,expressed,bacterial,genera,results,revealed,six,intestinal,seven,mediated,amino,acid,carbohydrate,cofactors,vitamins,lipid,mice,Besides,expression,eight,regulated,these,metabolisms,after,administration,Overall,findings,demonstrate,associated,disorders,microbial,dysbiosis,Further,present,exerts,improving,through,flora
AB值：
0.492112
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