Hyphenated LC-ABTS+and LC-DAD-HRMS for simultaneous analysis and identification of antioxidant compounds in Astragalus emarginatus Labill.extracts|Abir Chamandy;Minjie Zhao;Hassan Rammal;Sa?d Ennahar|Research Platform of Analysis and Environmental Science(PRASE),Lebanese University,Hadath,005,Lebanon - 期刊导航|首站-论文投稿智能助手|论文发表|论文智能投稿|期刊自助发表推荐|杂志社快速发表|查同导刊-域田数据官方网站

典型文献

Hyphenated LC-ABTS+and LC-DAD-HRMS for simultaneous analysis and identification of antioxidant compounds in Astragalus emarginatus Labill.extracts

文献摘要：

The compounds in leaf and stem extracts of Astragalus emarginatus Labill.(AEL),a plant species used in traditional Lebanese medicine,were investigated for antioxidant properties.First,the activity of various extracts was assessed using the Trolox equivalent antioxidant capacity,oxygen radical absorption ca-pacity,and 2,2-diphenyl-1-picryl-hydrazy l-hydrate assays.The extract obtained using 30％ethanol showed the greatest activity.The antioxidant compounds in this extract were screened using a hy-phenated high-performance liquid chromatography-2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate)radical(ABTS+)system before being separated by ultra-high-performance liquid chromatography and identified using high-resolution mass spectrometry and ultra-violet-visible diode array detection.Approximately 40 compounds were identified.Hydroxycinnamates(caffeic,ferulic,and p-coumaric acid derivatives)and flavonoids(quercetin,luteolin,apigenin,and isorhamnetin derivatives)were the two main categories of the identified compounds.The active compounds were identified as caffeic acid de-rivatives and quercetin glycosides.In addition,the catechol moiety was shown to be key to antioxidant activity.This study showed that AEL is a source of natural antioxidants,which may explain its medicinal use.

文献关键词：

中图分类号：

[1] 医药、卫生（R） / 药学（R9） / 药理学（R96） / 实验药理学（R965）

[2] 医药、卫生（R） / 基础医学（R3） / 病理学（R36） / 病理过程（R364）

[3] 数理科学和化学（O） / 力学（O3） / 振动理论（O32） / 非线性振动（O322）

作者姓名：

Abir Chamandy;Minjie Zhao;Hassan Rammal;Sa?d Ennahar

作者机构：

Analytical Chemistry of Bioactive Molecules and Pharmacognosy Team(CAMBAP),Hubert Curien Multidisciplinary Institute(IPHC),National Center for Scientific Research(CNRS),Faculty of Pharmacy,University of Strasbourg,Illkirch,67400,France;Research Platform of Analysis and Environmental Science(PRASE),Lebanese University,Hadath,005,Lebanon;Faculty of Agronomy,Lebanese University,Dekwaneh,005,Lebanon

文献出处：

药物分析学报（英文）

引用格式：

[1]Abir Chamandy;Minjie Zhao;Hassan Rammal;Sa?d Ennahar-.Hyphenated LC-ABTS+and LC-DAD-HRMS for simultaneous analysis and identification of antioxidant compounds in Astragalus emarginatus Labill.extracts)[J].药物分析学报（英文）,2022(02):253-262

A类：

Hyphenated,ABTS+and,emarginatus,Labill,Lebanese,hydrazy,phenated,Hydroxycinnamates

B类：

LC,DAD,HRMS,simultaneous,analysis,identification,compounds,Astragalus,extracts,leaf,AEL,plant,species,used,traditional,medicine,were,investigated,properties,First,activity,various,was,assessed,using,Trolox,equivalent,capacity,oxygen,radical,absorption,diphenyl,picryl,hydrate,assays,obtained,ethanol,showed,greatest,this,screened,high,performance,liquid,chromatography,azinobis,ethylbenzothiazoline,sulfonate,system,before,being,separated,by,ultra,identified,resolution,mass,spectrometry,violet,visible,diode,array,detection,Approximately,caffeic,ferulic,coumaric,acid,derivatives,flavonoids,quercetin,luteolin,apigenin,isorhamnetin,two,main,categories,active,glycosides,In,addition,catechol,moiety,shown,key,This,study,that,source,natural,antioxidants,which,may,explain,its,medicinal

AB值：

0.534839

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