典型文献
The protective effects of peptides from Chinese baijiu on AAPH-induced oxidative stress in HepG2 cells via Nrf2 signaling pathway
文献摘要：
Antioxidant peptides have been widely reported. However, only a few reports have been published examining the antioxidant peptides derived from Chinese baijiu. In this study, 6 novel peptides derived from Chinese baijiu were identified successfully using high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (HPLC-QTOF-MS) with a concentration of 0.835–24.540 μg/L. The underlying molecular mechanisms were investigated, and their cytoprotective effects were examined against 2,2'-azobis (2-methylpropanimidamidine) dihydrochloride (AAPH)-induced oxidative stress in HepG2 cells. The results showed that these peptides exerted protective effects by suppressing reactive oxygen species (ROS) generation, preventing malondialdehyde (MDA) formation, and upregulating cellular antioxidant enzyme activities (SOD, CAT, and GSH-Px) in a dose-dependent manner. Further experiments proved that these peptides exerted antioxidant effects via Nrf2/ARE-mediated signaling pathway by promoting Nrf2 nuclear translocation, inhibiting ubiquitination, and enhancing transcription capacity of Nrf2 in HepG2 cells. These findings provide the molecular basis for the effects of antioxidant peptides derived from Chinese baijiu, which is important for a deeper understanding of the relationship between human health and moderate drinking.
文献关键词：
中图分类号：
作者姓名：
Jiaying Huo;Yuezhang Ming;Huifeng Li;Anjun Li;Jiwen Zhao;Mingquan Huang;Weizheng Sun;Jihong Wu;Jinglin Zhang
作者机构：
Key Laboratory of Brewing Molecular Engineering of China Light Industry,Beijing Technology and Business University,Beijing 100048,China;School of Food Science and Engineering,South China University of Technology,Guangzhou 510640,China;Inner Mongolia Taibusiqi Grassland King Wine Co.,Ltd.,Inner Mongolia 027000,China;Anhui Gujing Distillery Co.,Ltd.,Anhui 236000,China;Shandong Bandaojing Co.,Ltd.,Shandong 256300,China
文献出处：
引用格式：
[1]Jiaying Huo;Yuezhang Ming;Huifeng Li;Anjun Li;Jiwen Zhao;Mingquan Huang;Weizheng Sun;Jihong Wu;Jinglin Zhang-.The protective effects of peptides from Chinese baijiu on AAPH-induced oxidative stress in HepG2 cells via Nrf2 signaling pathway)[J].食品科学与人类健康（英文）,2022(06):1527-1538
A类：
baijiu,cytoprotective,methylpropanimidamidine
B类：
effects,peptides,from,Chinese,AAPH,induced,oxidative,stress,HepG2,cells,via,Nrf2,signaling,pathway,Antioxidant,have,been,widely,reported,However,only,few,reports,published,examining,antioxidant,derived,In,this,study,novel,were,identified,successfully,using,high,performance,liquid,chromatography,quadrupole,flight,mass,spectrometry,HPLC,QTOF,concentration,underlying,molecular,mechanisms,investigated,their,examined,against,azobis,dihydrochloride,results,showed,that,these,exerted,by,suppressing,reactive,oxygen,species,ROS,generation,preventing,malondialdehyde,formation,upregulating,cellular,enzyme,activities,CAT,GSH,Px,dose,dependent,manner,Further,experiments,proved,ARE,mediated,promoting,nuclear,translocation,inhibiting,ubiquitination,enhancing,transcription,capacity,These,findings,provide,basis,which,important,deeper,understanding,relationship,between,human,health,moderate,drinking
AB值：
0.594305
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