典型文献
Label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip
文献摘要：
Surface-enhanced Raman scattering (SERS), owing to its high sensitivity based on localized surface plasmon reson-ance of nanostructured metals, is recently attracting much attention to be used for biotechnology, such as cell imaging and tumor therapy. On the other hand, the trace detection of bio-molecules with large molecular weight is still challen-ging because the troublesome treatment of SERS substrate using coupling or cross-linking agents is required. In this pa-per, we apply liquid interface assisted SERS (LI-SERS) method, which provides unique features of collection and self-im-mobilization of analyte molecules on the SERS substrate, to realize the label-free trace detection of bio-molecules with detection limits of pM ～ fM. Specifically, deoxyribonucleic acid (DNA) discrimination and quantitative detection of β-Amyl-oid (Aβ) in trace-concentration are demonstrated to illustrate the ultrahigh sensitivity and versatility of the LI-SERS meth-od. The results suggest LI-SERS is promising for the early-stage diagnosis of diseases such as virus infection and Alzheimer's disease.
文献关键词：
中图分类号：
作者姓名：
Shi Bai;Xueli Ren;Kotaro Obata;Yoshihiro Ito;Koji Sugioka
作者机构：
Advanced Laser Processing Research Team,RIKEN Center for Advanced Photonics,2-1 Hirosawa,Wako,Saitama 351-0198,Japan;Nano Medical Engineering Laboratory,RIKEN Cluster for Pioneering Research,2-1 Hirosawa,Wako,Saitama 351-0198,Japan
文献出处：
引用格式：
[1]Shi Bai;Xueli Ren;Kotaro Obata;Yoshihiro Ito;Koji Sugioka-.Label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip)[J].光电进展（英文版）,2022(10):12-21
A类：
reson,Amyl
B类：
Label,free,trace,detection,molecules,by,liquid,interface,assisted,surface,enhanced,Raman,scattering,using,microfluidic,chip,Surface,SERS,owing,sensitivity,localized,plasmon,nanostructured,metals,recently,attracting,much,attention,used,biotechnology,such,cell,imaging,tumor,therapy,On,other,hand,large,molecular,weight,still,challen,because,troublesome,treatment,substrate,coupling,cross,linking,agents,required,In,this,pa,per,apply,LI,method,which,provides,unique,features,collection,self,mobilization,analyte,realize,label,limits,pM,fM,Specifically,deoxyribonucleic,acid,discrimination,quantitative,oid,concentration,are,demonstrated,illustrate,ultrahigh,versatility,results,suggest,promising,early,stage,diagnosis,diseases,virus,infection,Alzheimer
AB值：
0.580289
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