Amyloid beta-peptide 1-42(Aβ1-42)is one of the biomarkers of Alzheimer's disease,and its selec-tive capture and quantitative detection are important for diagnosis and treatment of Alzheimer's disease.Herein,copper(Ⅱ)ions-immobilized virus-like hollow covalent organic frameworks(V-HCOFs@Cu2+)were synthesized by a facile approach.The as-prepared V-HCOFs@Cu2+showed unique morphology,ultra-high specific surface(2552 m2/g),uniform mesoporous structure(3.2 nm),superior chemical stability and abundant binding sites.Based on these excellent properties,the V-HCOFs@Cu2+could be adopted as an ideal enrichment probe for highly efficient capture of Aβ1-42,exhibiting high adsorption capac-ity(320 mg/g),and fast adsorption equilibration time(3 min).In addition,an attractive approach of the V-HCOFs@Cu2+-based matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)was de-veloped for the rapid screening and quantitative analysis of Aβ1-42 in human serum by using C-peptide as an internal standard,which exhibited low limit of detection(LOD,0.2 fmol/μL),and satisfactory recov-ery.This work provides an alternative solution for enrichment of biomarkers and also offers the potential applications of COFs in clinical analysis

Wende Ma;Chao Zhong;Juan Lin;Zhuling Chen;Guorong Li;Wei Tong;Yijing Wu;Lan Zhang;Zian Lin

Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology,Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety,College of Chemistry,Fuzhou University,Fuzhou 350108,China;Department of Cardiology,Fujian Provincial Governmental Hospital,Fuzhou 350003,China

中国化学快报（英文版）

[1]Wende Ma;Chao Zhong;Juan Lin;Zhuling Chen;Guorong Li;Wei Tong;Yijing Wu;Lan Zhang;Zian Lin-.Copper(Ⅱ)ions-immobilized virus-like hollow covalent organic frameworks for highly efficient capture and sensitive analysis of amyloid beta-peptide 1-42 by MALDI-MS)[J].中国化学快报（英文版）,2022(12):5174-5179

HCOFs,Cu2+showed,Cu2+could

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