Background:This study examined the joint associations of sleep patterns and physical activity(PA)with all-cause,cardiovascular disease(CVD),and cancer mortality.Methods:A total of 341,248 adults(mean age=39.7 years;men:48.3％)were included in the study,with a 15-year follow-up.Participants reported sleep duration and disturbances(difficulty falling asleep,easily awakened,or use of sleeping medication).PA was classified into 4 levels:＜7.5,7.5-14.9,15.0-29.9,and≥30.0 metabolic equivalent hours per week(MET-h/week).To understand the joint associations of sleep patterns and PA with mortality,Cox proportional hazard models were conducted,with exposure variables combining sleep duration/disturbances and PA.Results:Compared with the reference group(sleeping 6-8 h/day),individuals who slept＞8 h/day had higher risk for all-cause mortality(hazard ratio(HR)=1.307,95％confidence interval(95％CI):1.248-1.369),CVD mortality(HR=1.298,95％CI:1.165-1.445),and cancer mortality(HR=1.128,95％CI:1.042-1.220).Short sleep duration was not associated with mortality risk.Increased risk of all-cause and CVD mortality was found in participants who had difficulty falling asleep(HR=1.120,95％CI:1.068-1.175;HR=1.163,95％CI:1.038-1.304,respectively),and used sleeping medication(HR=1.261,95％CI:1.159-1.372;HR=1.335,95％CI:1.102-1.618,respectively)compared with those who slept well.Long sleep duration and sleep disturbances were not associated with risk of all-cause and CVD mortality among individuals achieving a PA level of≥15 MET-h/week,and in particular among those achieving≥30 MET-h/week.Conclusion:Long sleep duration,difficulty falling asleep,and use of sleeping medication were related to a higher risk of death.Being physically active at a moderate intensity for 25-65 min/day eliminated these detrimental associations.

Li-Jung Chen;Mark Hamer;Yun-Ju Lai;Bo-Huei Huang;Po-Wen Ku;Emmanuel Stamatakis

Department of Exercise Health Science,(National)Taiwan University of Sport,Taichung 40404,China;Institute of Sport Exercise and Health,Division of Surgery and Interventional Science,Faculty of Medical Sciences,University College London,London,WC1E 6BT UK;Division of Endocrinology and Metabolism,Department of Internal Medicine,Puli Branch of Taichung Veterans General Hospital,Nantou 54552,China;School of Medicine,(National)Yang-Ming University,Taipei 11221,China;Charles Perkins Centre,School of Health Sciences,Faculty of Medicine and Health,University of Sydney,Sydney,NSW 2006,Australia;Graduate Institute of Sports and Health,(National)Changhua University of Education,Changhua 50007,China;Department of Kinesiology,(National)Tsing Hua University,Hsinchu 30013,China

运动与健康科学（英文）

[1]Li-Jung Chen;Mark Hamer;Yun-Ju Lai;Bo-Huei Huang;Po-Wen Ku;Emmanuel Stamatakis-.Can physical activity eliminate the mortality risk associated with poor sleep?A 15-year follow-up of 341,248 MJ Cohort participants)[J].运动与健康科学（英文）,2022(05):596-604

awakened,slept

Can,activity,mortality,risk,associated,poor,follow,MJ,Cohort,participants,Background,This,study,examined,joint,associations,patterns,PA,cause,cardiovascular,disease,CVD,cancer,Methods,total,adults,mean,age,years,were,included,Participants,reported,duration,disturbances,difficulty,falling,asleep,easily,sleeping,medication,was,classified,into,levels,metabolic,equivalent,hours,per,week,MET,To,understand,Cox,proportional,hazard,models,conducted,exposure,variables,combining,Results,Compared,reference,group,day,individuals,who,had,higher,confidence,interval,Short,not,Increased,found,respectively,used,compared,those,well,Long,among,achieving,particular,Conclusion,related,death,Being,physically,active,moderate,intensity,eliminated,these,detrimental

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