典型文献
Association of baseline hemoglobin A1c levels with bleeding in patients with non-ST-segment elevation acute coronary syndrome underwent percutaneous coronary intervention:insights of a multicenter cohort study from China
文献摘要：
OBJECTIVE To investigate the association between baseline hemoglobin A1c (HbA1c) levels and bleeding in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) who underwent percutaneous coronary intervention (PCI). METHODS This observational cohort study enrolled 6283 consecutive NSTE-ACS patients undergoing PCI from January 1, 2010 to December 31, 2014. Based on baseline HbA1c levels, the patients were divided into the group with HbA1c < 7％ (n =4740) and the group with HbA1c ≥ 7％ (n = 1543). The primary outcomes are major bleeding (BARC grades 3-5) and all-cause death during follow-up. RESULTS Of patients enrolled, 4705 (74.9％) were male, and 2143 (34.1％) had a history of diabetes mellitus, with a mean (SD) age of 64.13 (10.32) years. The median follow-up duration was 3.21 years. Compared with the patients with HbA1c < 7％, the risk of major bleeding events during follow-up was higher in patients with HbA1c ≥ 7％ (adjusted hazard ratio [HR] = 1.57; 95％ con-fidence interval [CI]: 1.01-2.44; P = 0.044), while the risk of all-cause death during follow-up was not associated with the higher HbA1c levels (adjusted HR = 0.88; 95％ CI: 0.66-1.18; P = 0.398). CONCLUSIONS Compared with the lower baseline HbA1c levels, the higher baseline HbA1c levels were associated with an increase in long-term bleeding risk in NSTE-ACS patients undergoing PCI, though higher baseline HbA1c levels were not associ-ated with the higher risk in all-cause death.
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作者姓名：
Hua-Lin FAN;Li-Huan ZENG;Peng-Yuan CHEN;Yuan-Hui LIU;Chong-Yang DUAN;Wen-Fei HE;Ning TAN;Ji-Yan CHEN;Peng-Cheng HE
作者机构：
Department of Cardiology,School of Medicine,South China University of Technology,Guangzhou,China;Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China;Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China;The Second School of Clinical Medicine,Southern Medical University,Guangzhou,China;Department of Cardiology,the Second People's Hospital of Nanhai District,Guangdong Provincial People's Hospital's Nanhai Hospital,Foshan,China;De-partment of Biostatistics,School of Public Health,Southern Medical University,Guangzhou,China;Department of Cardiology,Heyuan People's Hospital,Heyuan,China
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引用格式：
[1]Hua-Lin FAN;Li-Huan ZENG;Peng-Yuan CHEN;Yuan-Hui LIU;Chong-Yang DUAN;Wen-Fei HE;Ning TAN;Ji-Yan CHEN;Peng-Cheng HE-.Association of baseline hemoglobin A1c levels with bleeding in patients with non-ST-segment elevation acute coronary syndrome underwent percutaneous coronary intervention:insights of a multicenter cohort study from China)[J].老年心脏病学杂志（英文版）,2022(07):487-497
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0.421513
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