典型文献
The characteristics of liver injury induced by Amanita and clinical value of α-amanitin detection
文献摘要：
Background:Amanita poisoning as a foodborne disease has raised concerning mortality issues.Reducing the interval between mushroom ingestion and medical intervention could greatly influence the outcomes of Amanita poisoning patients,while treatment is highly dependent on a confirmed diagnosis.To this end,we developed an early detection-guided intervention strategy by optimizing diagnostic process with performing α-amanitin detection,and further explored whether this strategy influenced the progression of Amanita poisoning.Methods:This study was a retrospective analysis of 25 Amanita poisoning patients.Thirteen patients in the detection group were diagnosed mainly based on α-amanitin detection,and 12 patients were di-agnosed essentially on the basis of mushroom consumption history,typical clinical patterns and mush-room identification(conventional group).Amanita poisoning patients received uniform therapy,in which plasmapheresis was executed once confirming the diagnosis of Amanita poisoning.We compared the de-mographic baseline,clinical and laboratory data,treatment and outcomes between the two groups,and further explored the predictive value of α-amanitin concentration in serum.Results:Liver injury induced by Amanita appeared worst at the fourth day and alanine aminotransferase(ALT)rose higher than aspartate aminotransferase(AST).The mortality rate was 7.7％(1/13)in the de-tection group and 50.0％(6/12)in the conventional group(P = 0.030),since patients in the detection group arrived hospital much earlier and received plasmapheresis at the early stage of disease.The early detection-guided intervention helped alleviate liver impairment caused by Amanita and decreased the peak AST as well as ALT.However,the predictive value of α-amanitin concentration in serum was still considered limited.Conclusions:In the management of mushroom poisoning,consideration should be given to the rapid detection of α-amanitin in suspected Amanita poisoning patients and the immediate initiation of medical treatment upon a positive toxin screening result.
文献关键词：
中图分类号：
作者姓名：
Li-Ying Lin;Ya-Ling Tong;Yuan-Qiang Lu
作者机构：
Department of Emergency Medicine,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;The Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province,Hangzhou 310003,China
文献出处：
引用格式：
[1]Li-Ying Lin;Ya-Ling Tong;Yuan-Qiang Lu-.The characteristics of liver injury induced by Amanita and clinical value of α-amanitin detection)[J].国际肝胆胰疾病杂志(英文版),2022(03):257-266
A类：
amanitin,agnosed,mographic
B类：
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AB值：
0.478488
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