典型文献
Clinical and Pathological Implications of Increases in Tonsillar CD19+CD5+B Cells,CD208+Dendritic Cells,and IgA1-positive Cells of Immunoglobulin A Nephropathy
文献摘要：
Objective:Several studies indicated that tonsillectomy can improve the prognosis of patients with immunoglobulin A nephropathy(IgAN).However,the relationship between tonsillar immunity and IgAN is still unclear.Methods:A total of 14 IgAN patients were recruited in the current study from May 2015 to April 2016 in Tongji Hospital.B cells,dendritic cells(DCs),and IgA1 positive cells in human tonsils were detected using immunofluorescence and immunohistochemistry.Correlations between these cells and clinicopathologic features were evaluated.Results:CD19+CD5+B cells were predominantly located in germinal centers and mantle zones of lymphoid follicles,the CD208+DCs were distributed in the interfollicular and subepithelial area,and IgAl-positive cells were predominantly detected in mantle zones of lymphoid follicles and subepithelial tissues.The numbers of CD19+CD5+B cells,CD208+DCs,and IgA1-positive cells in tonsillar tissues from IgAN patients were significantly higher than those in the normal controls(P＜0.01,respectively).CD19+CD5+B cells,CD208+DCs,and IgA1-positive cells in tonsillar tissues were significantly associated with 24-h proteinuria levels and tubular atrophy/interstitial fibrosis of IgAN.Conclusion:CD19+CD5+B cells,CD208+DCs,and IgA1-positive cells in tonsillar tissues might be involved in the pathogenesis of IgAN.
文献关键词：
中图分类号：
作者姓名：
Yang CAI;Mei-xue CHEN;Yuan-jun DENG;Le-le LIU;Xue-ping LIN;Ping-fan LU;Yi-yan GUO;Min HAN
作者机构：
Division of Nephrology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
文献出处：
引用格式：
[1]Yang CAI;Mei-xue CHEN;Yuan-jun DENG;Le-le LIU;Xue-ping LIN;Ping-fan LU;Yi-yan GUO;Min HAN-.Clinical and Pathological Implications of Increases in Tonsillar CD19+CD5+B Cells,CD208+Dendritic Cells,and IgA1-positive Cells of Immunoglobulin A Nephropathy)[J].当代医学科学(英文),2022(01):93-99
A类：
Tonsillar,CD19+CD5+B,CD208+Dendritic,tonsillectomy,tonsillar,tonsils,CD208+DCs,interfollicular,IgAl
B类：
Clinical,Pathological,Implications,Increases,Cells,IgA1,positive,Immunoglobulin,Nephropathy,Objective,Several,studies,indicated,that,improve,prognosis,patients,immunoglobulin,nephropathy,IgAN,However,relationship,between,immunity,still,unclear,Methods,total,were,recruited,current,study,from,May,April,Tongji,Hospital,cells,dendritic,human,detected,using,immunofluorescence,immunohistochemistry,Correlations,these,clinicopathologic,features,evaluated,Results,predominantly,located,germinal,centers,mantle,zones,lymphoid,follicles,distributed,subepithelial,area,tissues,numbers,significantly,higher,than,those,normal,controls,respectively,associated,proteinuria,levels,tubular,atrophy,interstitial,fibrosis,Conclusion,might,involved,pathogenesis
AB值：
0.439998
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