典型文献
Diabetes Is Not Associated with Increased 10-week Mortality Risk in Patients with Cryptococcal Meningitis
文献摘要：
Background::Diabetes is a risk factor for acquisition of cryptococcal meningitis (CM). However, the effects of diabetes on outcomes of CM patient have not been fully studied.Methods::In this retrospective study, 49 diabetic CM patients and 98 non-diabetic CM patients from January 2008 to December 2018 in the First Affiliated Hospital of Zhejiang University were included by propensity score-matched method (1:2). Demographic characteristics, symptoms, and clinical assay parameters between the two groups were compared. Kaplan-Meier analysis and Cox proportional hazards model were used to assess factors associated with 10-week mortality.Results::The mean age of diabetic patients was 58.2 ± 13.8 years; 71.4% (35/49) were more than 50 years old and 46.9% were male. No difference in symptoms was found between diabetic and non-diabetic CM patients. The Charlson comorbidity score was higher in the diabetic group (1.9
vs. 0.7,
P < 0.001). CM patients with diabetes had higher white blood cells count (×10
6/L, 111.0 (18.0- 242.5)
vs. 50.0 (10.0-140.0),
P=0.034) in cerebrospinal fluid (CSF), lower CSF India ink positivity (40.8%
vs. 60.2%,
P=0.039), and Cryptococcus culture positivity (42.9%
vs. 60.2%,
P=0.047). The overall 10-week survival rate was 79.7% in diabetic patients
vs. 83.2% in non-diabetic patients (log-rank
P=0.794).
Conclusion::Diabetic CM patients have higher CSF glucose and Charlson comorbidity score, but lower CSF India ink and culture positivity than non-diabetic CM patients. No difference in 10-week mortality was found between patients with and without diabetes. Other comorbidities may have a greater effect on prognosis.
文献关键词：
Cryptococcus;Clinical characteristics;Diabetes;Meningitis;Prognosis;Propensity score match study
中图分类号：
作者姓名：
Xu Lijun;Chen Ying;Zhou Minghan;Tao Ran;Guo Yongzheng;Lou Fangyuan;Yang Zongxing
作者机构：
National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China;The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China;School of Medicine, Zhejiang University, Hangzhou 310058, China;Department of HIV/AIDS, Xixi Hospital of Hangzhou, Hangzhou 310023, China
文献出处：
引用格式：
[1]Xu Lijun;Chen Ying;Zhou Minghan;Tao Ran;Guo Yongzheng;Lou Fangyuan;Yang Zongxing-.Diabetes Is Not Associated with Increased 10-week Mortality Risk in Patients with Cryptococcal Meningitis)[J].感染性疾病和免疫（英文）,2022(02):93-99
A类：
Cryptococcal,Meningitis
B类：
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AB值：
0.526459
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