典型文献
Cytotoxicity, Degradation and Release Behavior of Alginate Fibers Loaded with Chlorhexidine Gluconate and Its Docking Simulation
文献摘要：
To investigate the feasibility and safety of alginate fibers loaded with chlorhexidine gluconate ( CHG) for biomedical applications, vitro cytotoxic test and drug release pattern were studied. Discovery Studio ( DS) , a computer aided software, was utilized to briefly investigate the energy state and solvation at the molecular level. Alginate fiber loaded with CHG presented different drug release patterns in PBS and A solution. Cytotoxicity results indicated that CHG-loaded alginate fibers can promote the growth of L-929 mouse fibroblast cells with better biocompatibility. Through the simulation, the lowest energy conformation of three representative molecular bond regions was optimized with stronger stability. As the torsional energy increased, the bond energy of the target regions decreased. Besides, the transition energy of the target regions was greatly reduced by solvation. In a word, alginate fibers loaded with CHG expressed better biocompatibility and drug sustained-release ability, which indicates that CHG-loaded alginate fibers has a broad application prospect in medical dressing.
文献关键词：
中图分类号：
作者姓名：
Songsong Shi;Yuting Chen;Xinke Xia;Yuan'e Zhang;Minlu Feng;Shengjiao Lei
作者机构：
College of Biological and Pharmaceutical,China Three Gorges University,Yichang 443002,Hubei,China
文献出处：
引用格式：
[1]Songsong Shi;Yuting Chen;Xinke Xia;Yuan'e Zhang;Minlu Feng;Shengjiao Lei-.Cytotoxicity, Degradation and Release Behavior of Alginate Fibers Loaded with Chlorhexidine Gluconate and Its Docking Simulation)[J].哈尔滨工业大学学报（英文版）,2022(05):49-56
A类：
Chlorhexidine,Gluconate
B类：
Cytotoxicity,Degradation,Release,Behavior,Alginate,Fibers,Loaded,Its,Docking,Simulation,To,investigate,feasibility,safety,alginate,fibers,loaded,chlorhexidine,gluconate,CHG,biomedical,applications,vitro,cytotoxic,test,drug,release,were,studied,Discovery,Studio,DS,computer,aided,software,was,utilized,briefly,energy,state,solvation,molecular,level,presented,different,patterns,PBS,solution,results,indicated,that,can,promote,growth,mouse,fibroblast,cells,better,biocompatibility,Through,simulation,lowest,conformation,three,representative,bond,regions,optimized,stronger,stability,torsional,increased,target,decreased,Besides,transition,greatly,reduced,by,In,word,expressed,sustained,which,indicates,has,broad,prospect,dressing
AB值：
0.586905
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
