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Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats
文献摘要：
Near-infrared light (NIR)triggered transdermal drug delivery systems are of great interest due to their on-demand drug release,which enable to enhance drug treatment efficiency as well as reduce side effect.Herein,a NIR-triggered microneedle (MN) patch array has been fabricated through depositing the photothermal conversion agent and anti-diabetic drug-loaded polymer vesicles with upper critical solution temperature (UCST) into dissolvable polymer matrix.The UCST-type polymer has a clearing point temperature of 41 ℃ and the drug-loaded polymer vesicles present excellent NIR-triggered and temperature responsive drug release behavior in vitro due to the disassociation of polymer vesicles upon NIR irradiation.After applying MNs to diabetic rats,significant hypoglycemic effect is achieved upon interval NIR irradiation and the blood glucose concentration can decrease to normal state for several hours,which enables to achieve the goal of on-demand drug release.This work suggests that the NIR-triggered MN drug release device has a potential application in the treatment of diabetes,especially for those requiring an active drug release manner.
文献关键词：
中图分类号：
[1] 医药、卫生（R） / 基础医学（R3） / 病理学（R36） / 病理过程（R364）
[2] 医药、卫生（R） / 药学（R9） / 药理学（R96） / 实验药理学（R965）
[3] 医药、卫生（R） / 临床医学（R4） / 治疗学（R45） / 生物疗法（R456）
作者姓名：
Wei Hu;Ya-Wei Su;Yi-Kun Jiang;Wen-Di Fan;Song-Yue Cheng;Zai-Zai Tong;Chao Cen;Guo-Hua Jiang
作者机构：
College of Materials Science and Engineering and Institute of Smart Biomedical Materials,Zhejiang Sci-Tech University,Hangzhou 310018,China;Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China
文献出处：
高分子科学（英文版）
引用格式：
[1]Wei Hu;Ya-Wei Su;Yi-Kun Jiang;Wen-Di Fan;Song-Yue Cheng;Zai-Zai Tong;Chao Cen;Guo-Hua Jiang-.Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats)[J].高分子科学（英文版）,2022(02):157-165
A类：
Transdermal,transdermal,dissolvable,disassociation
B类：
Polymer,Vesicles,Upper,Critical,Solution,Temperature,Near,infrared,Light,triggered,Delivery,Metformin,Diabetic,Rats,light,NIR,drug,delivery,systems,great,interest,due,their,demand,release,which,enhance,treatment,efficiency,well,reduce,side,effect,Herein,microneedle,patch,array,has,been,fabricated,through,depositing,photothermal,conversion,agent,anti,diabetic,loaded,polymer,vesicles,upper,critical,solution,temperature,UCST,into,matrix,type,clearing,point,present,excellent,responsive,behavior,vitro,upon,irradiation,After,applying,MNs,rats,significant,hypoglycemic,achieved,interval,blood,glucose,concentration,decrease,normal,state,several,hours,enables,goal,This,work,suggests,that,device,potential,application,diabetes,especially,those,requiring,active,manner
AB值：
0.569488
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